Publications
- 2004
Efficient synthesis of protected cyclopropyl β-aspartylphosphates
Adams, L. A., Charmant, J. P. H., Cox, R. J., Walter, M. & Whittingham, W. G., 21 Feb 2004, In: Organic and Biomolecular Chemistry. 2, 4, p. 542-553 12 p.Research output: Contribution to journal › Article › Research › peer review
- 2003
Diastereoselective Synthesis of Cyclopropane Amino Acids Using Diazo Compounds Generated in Situ
Adams, L. A., Aggarwal, V. K., Bonnert, R. V., Bressel, B., Cox, R. J., Shepherd, J., De Vicente, J., Walter, M., Whittingham, W. G. & Winn, C. L., 28 Nov 2003, In: Journal of Organic Chemistry. 68, 24, p. 9433-9440 8 p.Research output: Contribution to journal › Article › Research › peer review
Rapid and flexible synthesis of 1-deoxy-D-xylulose-5-phosphate, the substrate for 1-deoxy-D-xylulose-5-phosphate reductoisomerase
Cox, R. J., De Andrés-Gómez, A. & Godfrey, C. R. A., 21 Sept 2003, In: Organic and Biomolecular Chemistry. 1, 18, p. 3173-3177 5 p.Research output: Contribution to journal › Article › Research › peer review
The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs
Reed, M. A. C., Schweizer, M., Szafranska, A. E., Arthur, C., Nicholson, T. P., Cox, R. J., Crosby, J., Crump, M. P. & Simpson, T. J., 7 Feb 2003, In: Organic and Biomolecular Chemistry. 1, 3, p. 463-471 9 p.Research output: Contribution to journal › Article › Research › peer review
First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: Evidence for the mechanism of chain length determination
Nicholson, T. P., Winfield, C., Westcott, J., Crosby, J., Simpson, T. J. & Cox, R. J., 1 Jan 2003, In: Chemical communications. 3, 6, p. 686-687 2 p.Research output: Contribution to journal › Article › Research › peer review
- 2002
Biosynthesis
Cox, R. J., 12 Dec 2002, In: Annual Reports on the Progress of Chemistry - Section B. 98, p. 223-251 29 p.Research output: Contribution to journal › Article › Research › peer review
Aspartyl phosphonates and phosphoramidates: The first synthetic inhibitors of bacterial aspartate-semialdehyde dehydrogenase
Cox, R. J., Gibson, J. S., Belén, M. & Martín, M., 1 Dec 2002, In: CHEMBIOCHEM. 3, 9, p. 874-886 13 p.Research output: Contribution to journal › Article › Research › peer review
Synthesis and characterisation of acyl carrier protein bound polyketide analogues
Arthur, C., Cox, R. J., Crosby, J., Rahman, M. M., Simpson, T. J., Soulas, F., Spogli, R., Szafranska, A. E., Westcott, J. & Winfield, C. J., 1 Mar 2002, In: CHEMBIOCHEM. 3, 2-3, p. 253-257 5 p.Research output: Contribution to journal › Article › Research › peer review
Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site
Szafranska, A. E., Hitchman, T. S., Cox, R. J., Crosby, J. & Simpson, T. J., 5 Feb 2002, In: Biochemistry. 41, 5, p. 1421-1427 7 p.Research output: Contribution to journal › Article › Research › peer review
A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase
Adams, L. A., Cox, R. J., Gibson, J. S., Mayo-Martín, M. B., Walter, M. & Whittingham, W., 1 Jan 2002, In: Chemical communications. 2, 18, p. 2004-2005 2 p.Research output: Contribution to journal › Article › Research › peer review
Streptomyces coelicolor phosphopantetheinyl transferase: A promiscuous activator of polyketide and fatty acid synthase acyl carrier proteins
Cox, R. J., Crosby, J., Daltrop, O., Glod, F., Jarzabek, M. E., Nicholson, T. P., Reed, M., Simpson, T. J., Smith, L. H., Soulas, F., Szafranska, A. E. & Westcott, J., 1 Jan 2002, In: Journal of the Chemical Society. Perkin Transactions 1. 14, p. 1644-1649 6 p.Research output: Contribution to journal › Article › Research › peer review
Synthesis and in vitro enzyme activity of an oxa analogue of azi-DAP
Cox, R. J., Durston, J. & Roper, D. I., 1 Jan 2002, In: Journal of the Chemical Society. Perkin Transactions 1. 8, p. 1029-1035 7 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Biosynthesis
Cox, R. J., 2002, In: Annual Reports on the Progress of Chemistry - Section B.Research output: Contribution to journal › Article › Research › peer review
- 2001
Design and utility of oligonucleotide gene probes for fungal polyketide synthases
Nicholson, T. P., Rudd, B. A. M., Dawson, M., Lazarus, C. M., Simpson, T. J. & Cox, R. J., 1 Jan 2001, In: Chemistry and Biology. 8, 2, p. 157-178 22 p.Research output: Contribution to journal › Article › Research › peer review
Difluoromethylene analogues of aspartyl phosphate: The first synthetic inhibitors of aspartate semi-aldehyde dehydrogenase
Cox, R. J., Hadfield, A. T. & Mayo-Martín, M. B., 1 Jan 2001, In: Chemical communications. 1, 18, p. 1710-1711 2 p.Research output: Contribution to journal › Article › Research › peer review
Is N-acetylornithine aminotransferase the real N-succinyl-ll-diaminopimelate aminotransferase in Escherichia coli and Mycobacterium smegmatis?
Cox, R. J. & Wang, P. S. H., 1 Jan 2001, In: Journal of the Chemical Society. Perkin Transactions 1. 1, 17, p. 2006-2008 3 p.Research output: Contribution to journal › Comment/debate › Research › peer review
Synthesis and in vitro enzyme activity of aza, oxa and thia derivatives of bacterial cell wall biosynthesis intermediates
Cox, R. J. & Wang, P. S. H., 1 Jan 2001, In: Journal of the Chemical Society. Perkin Transactions 1. 1, 17, p. 2022-2034 13 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Stoichiometric analysis of the minimal actinorhodin polyketide synthase system
Nettleship, J. E., Cox, R. J. & Simpson, T. J., 2001, In: Amino Acids (Vienna).Research output: Contribution to journal › Article › Research › peer review
- 2000
Synthesis and in vitro enzyme activity of peptide derivatives of bacterial cell wall biosynthesis inhibitors
Cox, R. J., Jenkins, H., Schouten, J. A., Stentiford, R. A. & Wareing, K. J., 1 Dec 2000, In: Journal of the Chemical Society, Perkin Transactions 1. 13, p. 2023-2036 14 p.Research output: Contribution to journal › Article › Research › peer review
Bacterial diaminopimelate metabolism as a target for antibiotic design
Cox, R. J., Sutherland, A. & Vederas, J. C., May 2000, In: Bioorganic and Medicinal Chemistry. 8, 5, p. 843-871 29 p.Research output: Contribution to journal › Article › Research › peer review