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Prof. Dr.  Russell John Cox

https://orcid.org/0000-0002-1844-0157
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Publications

  1. 2011

  2. A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic

    Fukuda, D., Haines, A. S., Song, Z., Murphy, A. C., Hothersall, J., Stephens, E. R., Gurney, R., Cox, R. J., Crosby, J., Willis, C. L., Simpson, T. J. & Thomas, C. M., 7 Apr 2011, In: PLOS ONE. 6, 3, e18031.

    Research output: Contribution to journal › Article › Research › peer review

  3. Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390

    Murphy, A. C., Fukuda, D., Song, Z., Hothersall, J., Cox, R. J., Willis, C. L., Thomas, C. M. & Simpson, T. J., 28 Mar 2011, In: Angewandte Chemie . 50, 14, p. 3271-3274 4 p.

    Research output: Contribution to journal › Article › Research › peer review

  4. 2010

  5. First heterologous reconstruction of a complete functional fungal biosynthetic multigene cluster

    Heneghan, M. N., Yakasai, A. A., Halo, L. M., Song, Z., Bailey, A. M., Simpson, T. J., Cox, R. J. & Lazarus, C. M., 26 Jul 2010, In: CHEMBIOCHEM. 11, 11, p. 1508-1512 5 p.

    Research output: Contribution to journal › Article › Research › peer review

  6. Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase

    Skellam, E. J., Hurley, D., Davison, J., Lazarus, C. M., Simpson, T. J. & Cox, R. J., 26 Mar 2010, In: Molecular BioSystems. 6, 4, p. 680-682 3 p.

    Research output: Contribution to journal › Article › Research › peer review

  7. Solution structure of an acyl carrier protein domain from a fungal type i polyketide synthase

    Wattana-amorn, P., Williams, C., Ploskoń, E., Cox, R. J., Simpson, T. J., Crosby, J. & Crump, M. P., 16 Mar 2010, In: Biochemistry. 49, 10, p. 2186-2193 8 p.

    Research output: Contribution to journal › Article › Research › peer review

  8. Fungal type I polyketides

    Cox, R. J. & Simpson, T. J., 1 Mar 2010, Comprehensive Natural Products II: Chemistry and Biology. Elsevier Ltd., Vol. 1. p. 347-383 37 p.

    Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review

  9. Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase

    Fisch, K. M., Skellam, E., Ivison, D., Cox, R. J., Bailey, A. M., Lazarus, C. M. & Simpson, T. J., 2010, In: Chemical communications. 46, 29, p. 5331-5333 3 p.

    Research output: Contribution to journal › Article › Research › peer review

  10. Published

    Expression of complete fungal biosynthetic gene clusters by promoter replacement in Aspergillus oryzae

    Cox, R. J., Halo, L. M. & Heneghan, M. N., 2010, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Article › Research › peer review

  11. 13C Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae

    Wu, J., Zhang, H. B., Xu, J. L., Cox, R. J., Simpson, T. J. & Zhang, L. H., 2010, In: Chemical communications. 46, 2, p. 333-335 3 p.

    Research output: Contribution to journal › Article › Research › peer review

  12. 2009

  13. Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2)

    Evans, S. E., Williams, C., Arthur, C. J., Płoskoń, E., Wattana-amorn, P., Cox, R. J., Crosby, J., Willis, C. L., Simpson, T. J. & Crump, M. P., 12 Jun 2009, In: Journal of molecular biology. 389, 3, p. 511-528 18 p.

    Research output: Contribution to journal › Article › Research › peer review

  14. Preliminary kinetic analysis of acyl carrier protein-ketoacylsynthase interactions in the actinorhodin minimal polyketide synthase

    Beltran-Alvarez, P., Arthur, C. J., Cox, R. J., Crosby, J., Crump, M. P. & Simpson, T. J., 5 May 2009, In: Molecular BioSystems. 5, 5, p. 511-518 8 p.

    Research output: Contribution to journal › Article › Research › peer review

  15. Chapter 3 Fungal Type I Polyketide Synthases

    Cox, R. J. & Simpson, T. J., 14 Apr 2009, Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates. Hopwood, D. (ed.). B ed. p. 49-78 30 p. (Methods in Enzymology; vol. 459, no. B).

    Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review

  16. 2008

  17. Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus beauveria bassiana

    Halo, L. M., Heneghan, M. N., Yakasai, A. A., Song, Z., Williams, K., Bailey, A. M., Cox, R. J., Lazarus, C. M. & Simpson, T. J., 31 Dec 2008, In: Journal of the American Chemical Society. 130, 52, p. 17988-17996 9 p.

    Research output: Contribution to journal › Article › Research › peer review

  18. In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: The "leaky hosepipe" mechanism

    Wu, J., Hothersall, J., Mazzetti, C., O'Connell, Y., Shields, J. A., Rahman, A. S., Cox, R. J., Crosby, J., Simpson, T. J., Thomas, C. M. & Willis, C. L., 16 Jun 2008, In: CHEMBIOCHEM. 9, 9, p. 1500-1508 9 p.

    Research output: Contribution to journal › Article › Research › peer review

  19. Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires cooexpression with an enoyl reductase

    Halo, L. M., Marshall, J. W., Yakasai, A. A., Song, Z., Butts, C. P., Crump, M. P., Heneghan, M., Bailey, A. M., Simpson, T. J., Lazarus, C. M. & Cox, R. J., 3 Mar 2008, In: CHEMBIOCHEM. 9, 4, p. 585-594 10 p.

    Research output: Contribution to journal › Article › Research › peer review

  20. The biosynthesis of polyketides, acyl tetramic acids and pyridones by filamentous fungi

    Cox, R. J., 1 Jan 2008, Exploitation of Fungi: Symposium of the British Mycological Society Held at the University of Manchester September 2005. Cambridge University Press, p. 25-44 20 p.

    Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review

  21. 2007

  22. Dissecting the component reactions catalyzed by the actinorhodin minimal polyketide synthase

    Beltran-Alvarez, P., Cox, R. J., Crosby, J. & Simpson, T. J., 18 Dec 2007, In: Biochemistry. 46, 50, p. 14672-14681 10 p.

    Research output: Contribution to journal › Article › Research › peer review

  23. The biosynthesis of polyketides, tetramic acids, and pyridones in fungi

    Cox, R. J., 10 Dec 2007, Polyketides Biosynthesis, Biological Activity, and Genetic Engineering. Rimando, A. & Baerson, S. (eds.). p. 33-47 15 p. (ACS Symposium Series; vol. 955).

    Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review

  24. The chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli

    Wong, U. & Cox, R. J., 18 Jul 2007, In: Angewandte Chemie . 46, 26, p. 4926-4929 4 p.

    Research output: Contribution to journal › Article › Research › peer review

  25. Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomonic acid B biosynthesis precedes pseudomonic acid A

    Hothersall, J., Wu, J., Rahman, A. S., Shields, J. A., Haddock, J., Johnson, N., Cooper, S. M., Stephens, E. R., Cox, R. J., Crosby, J., Willis, C. L., Simpson, T. J. & Thomas, C. M., 25 May 2007, In: Journal of Biological Chemistry. 282, 21, p. 15451-15461 11 p.

    Research output: Contribution to journal › Article › Research › peer review

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