Publications
2025
- E-pub ahead of print
Development of a novel disposable flowcell for spectroscopic bioprocess monitoring
Thiel, P., Steinwedel, T., Raithel, P., Belz, M. & Solle, D., Apr 2025, In: Measurement: Sensors. 38, 101862.Research output: Contribution to journal › Article › Research › peer review
- E-pub ahead of print
Machine Learning-Powered Optimization of a CHO Cell Cultivation Process
Richter, J., Wang, Q., Lange, F., Thiel, P., Yilmaz, N., Solle, D., Zhuang, X. & Beutel, S., 31 Jan 2025, (E-pub ahead of print) In: Biotechnology and bioengineering.Research output: Contribution to journal › Article › Research › peer review
2024
- Published
Application of a Novel Disposable Flow Cell for Spectroscopic Bioprocess Monitoring
Steinwedel, T., Raithel, P., Schellenberg, J., Kortmann, C., Gellermann, P., Belz, M. & Solle, D., 1 Oct 2024, In: Chemosensors. 12, 10, 202.Research output: Contribution to journal › Article › Research › peer review
- Published
A Novel 3D-Printed and Miniaturized Periodic Counter Current Chromatography System for Continuous Purification of Monoclonal Antibodies
Kortmann, C., Habib, T., Heuer, C., Solle, D. & Bahnemann, J., 13 Mar 2024, In: Micromachines. 15, 3, 17 p., 382.Research output: Contribution to journal › Article › Research › peer review
2023
- Published
Establishment of a Perfusion Process with Antibody-Producing CHO Cells Using a 3D-Printed Microfluidic Spiral Separator with Web-Based Flow Control
Schellenberg, J., Dehne, M., Lange, F., Scheper, T., Solle, D. & Bahnemann, J., Jun 2023, In: Bioengineering. 10, 6, 656.Research output: Contribution to journal › Article › Research › peer review
- Published
3D-Druck zur Miniaturisierung von chromatographischen Anwendungen
Kortmann, C., Habib, T., Solle, D. & Bahnemann, J., 31 May 2023, In: BioSpektrum. 29, 3, p. 276-277 2 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Digitale Zwillinge in der Bioprozesstechnik – Chancen und Möglichkeiten
RIchter, J., Lange, F., Scheper, T., Solle, D. & Beutel, S., 22 Mar 2023, In: Chemie-Ingenieur-Technik. 95, 4, p. 498-510 13 p.Research output: Contribution to journal › Article › Research
- Published
Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibodies
Wohlenberg, O. J., Kortmann, C., Meyer, K. V., Scheper, T. & Solle, D., 2 Feb 2023, In: Engineering in life sciences. 23, 2, e202200056.Research output: Contribution to journal › Article › Research › peer review
2022
- Published
Optimization of a mAb production process with regard to robustness and product quality using quality by design principles
Wohlenberg, O. J., Kortmann, C., Meyer, K. V., Schellenberg, J., Dahlmann, K., Bahnemann, J., Scheper, T. & Solle, D., Jul 2022, In: Engineering in life sciences. 22, 7, p. 484-494 11 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Stress-induced increase of monoclonal antibody production in CHO cells
Schellenberg, J., Nagraik, T., Wohlenberg, O. J., Ruhl, S., Bahnemann, J., Scheper, T. & Solle, D., May 2022, In: Engineering in life sciences. 22, 5, p. 427-436 10 p.Research output: Contribution to journal › Article › Research › peer review
2021
- Published
Monitoring cell productivity for the production of recombinant proteins by flow cytometry: An effective application using the cold capture assay
Meyer, K. V., Siller, I. G., Schellenberg, J., Gonzalez Salcedo, A., Solle, D., Matuszczyk, J., Scheper, T. & Bahnemann, J., May 2021, In: Engineering in life sciences. 21, 5, p. 288-293 6 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Disposable flowcell for spectroscopic analysis in bioprocesses
Raithel, P., Steinwedel, T., Belz, M. & Solle, D., 5 Mar 2021, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXI. Gannot, I. & Roodenko, K. (eds.). Bellingham: SPIE, 8 p. 1163514. (Proceedings of SPIE; vol. 11635)(Progress in biomedical optics and imaging; vol. 22, no. 27).Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
- Published
Implementation of QbD strategies in the inoculum expansion of a mAb production process
Böhl, O. J., Schellenberg, J., Bahnemann, J., Hitzmann, B., Scheper, T. & Solle, D., 2 Mar 2021, In: Engineering in life sciences. 21, 3-4, p. 196-207 12 p.Research output: Contribution to journal › Article › Research › peer review
2020
- Published
Development and characterization of a fiber optical fluorescence sensor for the online monitoring of biofilms and their microenvironment
Schlaugat, J., Patzer, K., Hentrop, T., Solle, D., Pepelanova, I., Schröder, U. & Scheper, T., 6 Jul 2020, In: Engineering in life sciences. 20, 7, p. 252-264 13 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Be FAIR to your data
Solle, D., Jul 2020, In: Analytical and Bioanalytical Chemistry. 412, 17, p. 3961-3965 5 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Process optimization using high throughput automated micro-bioreactors in chinese hamster ovary cell cultivation
Nagraik, T., Salcedo, A. G., Solle, D. & Scheper, T., 18 May 2020, In: Journal of visualized experiments. 2020, 159, e60577.Research output: Contribution to journal › Article › Research › peer review
2019
- Published
Online monitoring of the cell-specific oxygen uptake rate with an in situ combi-sensor
Dahlmann, K., Busse, C., Aupert, F., de Vries, I., Marquard, D., Solle, D., Lammers, F. & Scheper, T., 4 Dec 2019, In: Analytical and Bioanalytical Chemistry. 412, 9, p. 2111-2121 11 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Membrane Adsorber for the Fast Purification of a Monoclonal Antibody Using Protein A Chromatography
Brämer, C., Tünnermann, L., Salcedo, A. G., Reif, O. W., Solle, D., Scheper, T. & Beutel, S., Dec 2019, In: Membranes. 9, 12, 159.Research output: Contribution to journal › Article › Research › peer review
- Published
High cell density transient transfection of CHO cells for TGF-β1 expression
Elshereef, A. A., Jochums, A., Lavrentieva, A., Stuckenberg, L., Scheper, T. & Solle, D., 4 Nov 2019, In: Engineering in life sciences. 19, 11, p. 730-740 11 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Sensors for disposable bioreactor systems
Steinwedel, T., Dahlmann, K., Solle, D., Scheper, T., Reardon, K. F. & Lammers, F., 5 Aug 2019, Single-Use Technology in Biopharmaceutical Manufacture. Eibl, R. & Eibl, D. (eds.). 2. ed. Wiley-Blackwell, p. 69-82 14 p.Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
- Published
A novel LED-based 2D-fluorescence spectroscopy system for in-line bioprocess monitoring of Chinese hamster ovary cell cultivations—Part II
Claßen, J., Graf, A., Aupert, F., Solle, D., Höhse, M. & Scheper, T., 6 May 2019, In: Engineering in life sciences. 19, 5, p. 341-351 11 p.Research output: Contribution to journal › Article › Research › peer review
- Published
A novel LED-based 2D-fluorescence spectroscopy system for in-line monitoring of Chinese hamster ovary cell cultivations – Part I
Graf, A., Claßen, J., Solle, D., Hitzmann, B., Rebner, K. & Hoehse, M., 6 May 2019, In: Engineering in life sciences. 19, 5, p. 352-362 11 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Impact of stress on the productivity in mammalian cells
Schellenberg, J., Nagraik, T., Bahnemann, J., Solle, D. & Scheper, T., 2019.Research output: Contribution to conference › Poster › Research
2018
- Published
Thesenpapier Nationale Forschungsdateninfrastruktur für die Chemie (NFDI4Chem)
Koepler, O., Jung, N., Kraft, A., Neumann, J., Auer, S. (Contributor), Bach, F. (Contributor), Bähr, T. (Contributor), Engel, T. (Contributor), Kettner, C. (Contributor), Kowol-Santen, J. (Contributor), Liermann, J. (Contributor), Lipp, A. (Contributor), Porzel, A. (Contributor), Razum, M. (Contributor), Schlörer, N. (Contributor), Solle, D. (Contributor) & Winkler, T. (Contributor), 27 Aug 2018, Zenodo, 15 p.Research output: Working paper/Preprint › Working paper/Discussion paper
- Published
Development and characterisation of a new fluorescence sensor for online monitoring of bioprocesses
König, J. C., Steinwedel, T., Solle, D., Lindner, P., De Vries, I., Hentrop, T., Findeis, M., John, G. T., Scheper, T. & Beutel, S., 8 Aug 2018, In: Journal of Sensors and Sensor Systems. 7, 2, p. 461-467 7 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Produktaufreinigung und Produktanalytik in der Tierzellkultivierung
Mehl, A., Solle, D., Bahnemann, J. & Scheper, T., 2018.Research output: Contribution to conference › Slides to presentation › Research
2017
- Published
Continuous noninvasive monitoring of cell growth in disposable bioreactors
Reinecke, T., Biechele, P., Sobocinski, M., Suhr, H., Bakes, K., Solle, D., Jantunen, H., Scheper, T. & Zimmermann, S., Nov 2017, In: Sensors and Actuators, B: Chemical. 251, p. 1009-1017 9 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Differential Inductive Sensor for Continuous Non-Invasive Cell Growth Monitoring in Disposable Bioreactors
Allers, M., Reinecke, T., Nagraik, T., Solle, D., Bakes, K., Berger, M., Scheper, T. & Zimmermann, S., 16 Aug 2017, Proceedings of Eurosensors 2017: Paris, France, 3-6 September 2017. 4 ed. Vol. 1. 5 p. 518. (Proceedings).Research output: Chapter in book/report/conference proceeding › Conference contribution › Research
- Published
Sensors for disposable bioreactors
Busse, C., Biechele, P., de Vries, I., Reardon, K. F., Solle, D. & Scheper, T., Aug 2017, In: Engineering in life sciences. 17, 8, p. 940-952 13 p.Research output: Contribution to journal › Review article › Research › peer review
- Published
Between the Poles of Data-Driven and Mechanistic Modeling for Process Operation
Solle, D., Hitzmann, B., Herwig, C., Pereira Remelhe, M., Ulonska, S., Wuerth, L., Prata, A. & Steckenreiter, T., 6 Apr 2017, In: Chemie-Ingenieur-Technik. 89, 5, p. 542-561 20 p.Research output: Contribution to journal › Article › Research
- Published
Spectroscopic sensors for in-line bioprocess monitoring in research and pharmaceutical industrial application
Claßen, J., Aupert, F., Reardon, K. F., Solle, D. & Scheper, T., Jan 2017, In: Analytical and Bioanalytical Chemistry. 409, 3, p. 651-666 16 p.Research output: Contribution to journal › Review article › Research › peer review
- Published
Evaluation of Driving Forces for Protein Partition in PEG-Salt Aqueous Two- Phase Systems and Optimization by Design of Experiments
Glyk, A., Solle, D., Scheper, T. & Beutel, S., 2017, In: Journal of chromatography & separation techniques. 8, 6Research output: Contribution to journal › Article › Research
2016
- Published
Spektroskopische Sensornetzwerke zur intelligenten Bioprozessüberwachung
Solle, D., Aupert, F., Claßen, J. & Scheper, T., Sept 2016, In: Chemie-Ingenieur-Technik. 88, 9, 1 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Spektroskopische und wissensbasierte Bioprozessüberwachung von CHO-Zellkultivierungen
Claßen, J., Solle, D. & Scheper, T., Sept 2016, In: Chemie-Ingenieur-Technik. 88, 9, 1 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Batch-to-Perfusion Cultivation with Knowledge-Based and Spectroscopic Bioprocess Monitoring
Biechele, P., Solle, D. & Scheper, T., 29 Aug 2016, In: Chemie-Ingenieur-Technik. 88, 9, p. 1406-1407 2 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Multivariate Batch‐Modelle zur spektroskopiebasierten Überwachung von CHO‐Kultivierungen
Aupert, F., Solle, D. & Scheper, T., 29 Aug 2016, In: Chemie-Ingenieur-Technik. 88, 9, 1 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Spectroscopic methods and their applicability for high-throughput characterization of mammalian cell cultures in automated cell culture systems
Musmann, C., Joeris, K., Markert, S., Solle, D. & Scheper, T., 15 Jul 2016, In: Engineering in life sciences. 16, 5, p. 405-416 12 p.Research output: Contribution to journal › Article › Research
2015
- Published
A novel measuring chamber and automation platform for mammalian cell culture processes
Lücking, T., Busse, C., Lüder, C., Bulnes-Abundis, D., Solle, D. & Scheper, T., 14 Dec 2015, In: BMC proceedings. 9, Supplement 9Research output: Contribution to journal › Conference article › Research
- Published
Optimization of PEG-salt aqueous two-phase systems by design of experiments
Glyk, A., Solle, D., Scheper, T. & Beutel, S., 9 Oct 2015, In: Chemometrics and Intelligent Laboratory Systems. 149, p. 12-21 10 p.Research output: Contribution to journal › Review article › Research › peer review
- Published
Sensor systems for bioprocess monitoring
Biechele, P., Busse, C., Solle, D., Scheper, T. & Reardon, K., 8 Apr 2015, In: Engineering in life sciences. 15, 5, p. 469-488 20 p.Research output: Contribution to journal › Article › Research
2014
- Published
In situ microscopy and MIR-spectroscopy as non-invasive optical sensors for cell cultivation process monitoring
Lüder, C., Lindner, P., Bulnes-Abundis, D., Lu, S. M., Lücking, T., Solle, D. & Scheper, T., 2014, In: Pharmaceutical Bioprocessing. 2, 2Research output: Contribution to journal › Article › Research
2013
- Published
NIR Spectroscopy for Process Monitoring and Control in Mammalian Cell Cultivation
Sandor, M., Rüdinger, F., Solle, D., Bienert, R., Grimm, C. & Scheper, T., Sept 2013, In: BioProcess International. 11, 8, p. 40-48 9 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations
Sandor, M., Rüdinger, F., Bienert, R., Grimm, C., Solle, D. & Scheper, T., 12 Aug 2013, In: Journal of biotechnology. 168, 4, p. 636-645 10 p.Research output: Contribution to journal › Article › Research › peer review
- Published
NIR-spectroscopy for bioprocess monitoring & control
Sandor, M., Rüdinger, F., Solle, D., Bienert, R., Grimm, C., Groß, S. & Scheper, T., 2013.Research output: Contribution to conference › Poster › Research
- Published
Optimization of polymer/salt aqueous two-phase extraction of BSA by DoE
Glyk, A., Elea, H., Solle, D., Beutel, S. & Scheper, T., 2013Research output: Other contribution › Other publication › Research
2012
- Published
Evaluation der Infrarotspektroskopie zur Beobachtung und Regelung von Tierzellkultivierungen
Solle, D., Sandor, M., Rüdinger, F., Bienert, R., Grimm, C. & Scheper, T., 25 Jul 2012, In: Chemie Ingenieur Technik. 84, 8Research output: Contribution to journal › Other contribution to journal › Research
- Published
Überwachung von Bioprozessen mithilfe der NIR‐Spektroskopie
Bienert, R., Sandor, M., Rüdinger, F., Solle, D., Grimm, C. & Scheper, T., 25 Jul 2012, In: Chemie Ingenieur Technik. 84, 8Research output: Contribution to journal › Other contribution to journal › Research
- Published
Überwachung von CHO‐Kultivierungen mit verschiedenen spektroskopischen Methoden
Rüdinger, F., Sandor, M., Bienert, R., Solle, D., Grimm, C. & Scheper, T., 25 Jul 2012, In: Chemie Ingenieur Technik. 84, 8Research output: Contribution to journal › Other contribution to journal › Research
- Published
Monitoring baking processes of bread rolls by digital image analysis
Paquet-Durand, O., Solle, D., Schirmer, M., Becker, T. & Hitzmann, B., Jul 2012, In: Journal of food engineering. 111, 2, p. 425-431 7 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Chemometric modeling and two-dimensional fluorescence analysis of bioprocess with a new strain of Klebsiella pneumoniae to convert residual glycerol into 1,3-propanediol
Rossi, D. M., Solle, D., Hitzmann, B. & Ayub, M. A. Z., 1 May 2012, In: Journal of Industrial Microbiology and Biotechnology. 39, 5, p. 701-708 8 p.Research output: Contribution to journal › Article › Research › peer review
2011
- Published
In-situ microscopy and 2D fluorescence spectroscopy as online methods for monitoring CHO cells during cultivation
Bonk, S., Sandor, M., Rüdinger, F., Tscheschke, B., Prediger, A., Babitzky, A., Solle, D., Beutel, S. & Scheper, T., 22 Nov 2011, In: BMC proceedings. 5, Supplement 8Research output: Contribution to journal › Conference article › Research
2010
- Published
Fluorescence spectroscopy as a novel method for on-line analysis of biocatalytic C-C bond formations
Kara, S., Anton, F., Solle, D., Neumann, M., Hitzmann, B., Scheper, T. & Liese, A., 16 Apr 2010, In: Journal of Molecular Catalysis B: Enzymatic. 66, 1-2, p. 124-129 6 p.Research output: Contribution to journal › Article › Research › peer review
2009
- Published
Digital image analysis for the optimal control of bread and rolls baking
Solle, D., Hitzmann, B., Schirmer, M. & Becker, T., 2009, p. 666-671. 6 p.Research output: Contribution to conference › Paper › Research › peer review
2007
- External
Transcriptomics does not show adverse effects of β-carotene in A/J mice exposed to smoke for 2 weeks
Kuntz, E., Borlak, J., Riss, G., Aebischer, C. P., Bachmann, H., Seifert, N., Hunziker, P. B., Sölle, D., Hunziker, W., Goralczyk, R. & Wertz, K., 15 Sept 2007, In: Archives of Biochemistry and Biophysics. 465, 2, p. 336-346 11 p.Research output: Contribution to journal › Article › Research › peer review
2004
- Published
Modelling of an industrial biotransformation process for tryptophan production
Solle, D., Faurie, R., Breccia, J., Scheper, T. & Hitzmann, B., 2004, In: IFAC Proceedings Volumes (IFAC-PapersOnline). 37, 3, p. 189-193 5 p.Research output: Contribution to journal › Conference article › Research › peer review
2003
- Published
A New Evaluation Method for 2‐D Fluorescence Spectra Based on Theoretical Modeling
Geissler, D., Solle, D., Stärk, E., Scheper, T., Märkl, H. & Hitzmann, B., 8 Oct 2003, In: Engineering in Life Sciences. 3, 10Research output: Contribution to journal › Article › Research
- Published
Chemometric modelling with two-dimensional fluorescence data for Claviceps purpurea bioprocess characterization
Boehl, D., Solle, D., Hitzmann, B. & Scheper, T., 5 Sept 2003, In: Journal of biotechnology. 105, 1-2, p. 179-188 10 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Chemometric Modelling based on 2D-Fluorescence Spectra without a Calibration Measurement
Solle, D., Geissler, D., Stärk, E., Scheper, T. & Hitzmann, B., 22 Jan 2003, In: BIOINFORMATICS. 19, 2, p. 173-177 5 p.Research output: Contribution to journal › Article › Research › peer review
2002
- Published
Berechnung chemometrischer Modelle basierend auf theoretischen Modellen und 2D‐Fluoreszenzspektren
Geissler, D., Solle, D., Stärk, E., Scheper, T., Märkl, H. & Hitzmann, B., 19 Aug 2002, In: Chemie Ingenieur Technik. 74, 8Research output: Contribution to journal › Article › Research
2001
- Published
Use of Bioanalytical Systems for theImprovement of Industrial Tryptophan Production
Ulber, R., Protsch, C., Solle, D., Hitzmann, B., Willke, B., Faurie, R. & Scheper, T., 31 Jul 2001, In: Engineering in Life Sciences. 1, 1, p. 15-17 3 p.Research output: Contribution to journal › Article › Research › peer review
- Published
Optimierung der industriellen Tryptophanproduktion durch den Einsatz bioanalytischer Systeme
Ulber, R., Protsch, C., Solle, D., Hitzmann, B., Willke, B., Faurie, R. & Scheper, T., 16 May 2001, In: Chemie-Ingenieur-Technik. 73, 5, p. 524-526 3 p.Research output: Contribution to journal › Conference article › Research › peer review
- Published
Application of fluorescence spectroscopy for on-line bioprocess monitoring and control
Boehl, D., Solle, D., Toussaint, H. J., Menge, M., Renemann, G., Lindemann, C., Hitzmann, B. & Scheper, T., 13 Feb 2001, Optical Methods for Industrial Processes. Vol. 4201. p. 50-57 8 p. (Proceedings of SPIE - The International Society for Optical Engineering).Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
- Published
Anwendung der Fluoreszenzspektroskopie zur Beobachtung von Bierbrauprozessen
Bohl, D., Solle, D., Toussaint, H. J., Lindemann, C., Hitzemann, B. & Scheper, T., 2001, In: GIT-Laborfachzeitschrift. 45, 5, p. 512-515Research output: Contribution to journal › Article › Research
- Published
Einsatz bioanalytischer Systeme bei der industriellen Produktion von Pharmaaminosäuren
Ulber, R., Protsch, C., Solle, D., Hitzmann, B., Faurie, R. & Scheper, T., 2001.Research output: Contribution to conference › Other contribution published within the context of a conference › Research