Details
| Translated title of the contribution | Cyclic dinucleotides as molecular brake on development |
|---|---|
| Original language | German |
| Pages (from-to) | 482-484 |
| Number of pages | 3 |
| Journal | BioSpektrum |
| Volume | 26 |
| Issue number | 5 |
| Early online date | 5 Sept 2020 |
| Publication status | Published - Sept 2020 |
| Externally published | Yes |
Abstract
Streptomyces are renowned producers of antibiotics and other medically useful molecules. They undergo a developmental life cycle involving progression from vegetative growth to the erection of reproductive aerial hyphae, which differentiate into chains of spores. The second messengers c-di-GMP and c-di-AMP control this complex morphological transition. Studies on signalling mechanisms in this bacterial model led to the discovery of a tetrameric c-di-GMP, a sigma factor as an unexpected type of c-di-GMP effectors and a new class of c-di-AMP phosphodiesterases.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
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In: BioSpektrum, Vol. 26, No. 5, 09.2020, p. 482-484.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Zyklische Dinukleotide als molekulare Entwicklungsbremse
AU - Wörmann, Mirka E.
AU - Tschowri, Natalia
N1 - Publisher Copyright: © 2020, Der/die Autor(en). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - Streptomyces are renowned producers of antibiotics and other medically useful molecules. They undergo a developmental life cycle involving progression from vegetative growth to the erection of reproductive aerial hyphae, which differentiate into chains of spores. The second messengers c-di-GMP and c-di-AMP control this complex morphological transition. Studies on signalling mechanisms in this bacterial model led to the discovery of a tetrameric c-di-GMP, a sigma factor as an unexpected type of c-di-GMP effectors and a new class of c-di-AMP phosphodiesterases.
AB - Streptomyces are renowned producers of antibiotics and other medically useful molecules. They undergo a developmental life cycle involving progression from vegetative growth to the erection of reproductive aerial hyphae, which differentiate into chains of spores. The second messengers c-di-GMP and c-di-AMP control this complex morphological transition. Studies on signalling mechanisms in this bacterial model led to the discovery of a tetrameric c-di-GMP, a sigma factor as an unexpected type of c-di-GMP effectors and a new class of c-di-AMP phosphodiesterases.
UR - http://www.scopus.com/inward/record.url?scp=85090232487&partnerID=8YFLogxK
U2 - 10.1007/s12268-020-1430-2
DO - 10.1007/s12268-020-1430-2
M3 - Artikel
AN - SCOPUS:85090232487
VL - 26
SP - 482
EP - 484
JO - BioSpektrum
JF - BioSpektrum
SN - 0947-0867
IS - 5
ER -