Details
| Original language | English |
|---|---|
| Pages (from-to) | 508-517 |
| Number of pages | 10 |
| Journal | RSC Chemical Biology |
| Volume | 5 |
| Issue number | 6 |
| Early online date | 18 Apr 2024 |
| Publication status | Published - 2024 |
Abstract
The account attempts to substantiate the hypothesis that, from an evolutionary perspective, the coenzyme couple pyridoxal phosphate and pyridoxamine phosphate preceded the coenzyme thiamine pyrophosphate and acted as its less efficient chemical analogue in some form of early metabolism. The analysis combines mechanism-based chemical reactivity with biosynthetic arguments and provides evidence that vestiges of “TPP-like reactivity” are still found for PLP today. From these thoughts, conclusions can be drawn about the key elements of a primordial form of metabolism, which includes the citric acid cycle, amino acid biosynthesis and the pentose phosphate pathway.
ASJC Scopus subject areas
- Chemistry(all)
- Chemistry (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
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In: RSC Chemical Biology, Vol. 5, No. 6, 2024, p. 508-517.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Why pyridoxal phosphate could be a functional predecessor of thiamine pyrophosphate and speculations on a primordial metabolism
AU - Kirschning, Andreas
N1 - Publisher Copyright: © 2024 RSC.
PY - 2024
Y1 - 2024
N2 - The account attempts to substantiate the hypothesis that, from an evolutionary perspective, the coenzyme couple pyridoxal phosphate and pyridoxamine phosphate preceded the coenzyme thiamine pyrophosphate and acted as its less efficient chemical analogue in some form of early metabolism. The analysis combines mechanism-based chemical reactivity with biosynthetic arguments and provides evidence that vestiges of “TPP-like reactivity” are still found for PLP today. From these thoughts, conclusions can be drawn about the key elements of a primordial form of metabolism, which includes the citric acid cycle, amino acid biosynthesis and the pentose phosphate pathway.
AB - The account attempts to substantiate the hypothesis that, from an evolutionary perspective, the coenzyme couple pyridoxal phosphate and pyridoxamine phosphate preceded the coenzyme thiamine pyrophosphate and acted as its less efficient chemical analogue in some form of early metabolism. The analysis combines mechanism-based chemical reactivity with biosynthetic arguments and provides evidence that vestiges of “TPP-like reactivity” are still found for PLP today. From these thoughts, conclusions can be drawn about the key elements of a primordial form of metabolism, which includes the citric acid cycle, amino acid biosynthesis and the pentose phosphate pathway.
UR - http://www.scopus.com/inward/record.url?scp=85191851868&partnerID=8YFLogxK
U2 - 10.1039/d4cb00016a
DO - 10.1039/d4cb00016a
M3 - Review article
AN - SCOPUS:85191851868
VL - 5
SP - 508
EP - 517
JO - RSC Chemical Biology
JF - RSC Chemical Biology
IS - 6
ER -