Details
| Original language | English |
|---|---|
| Pages (from-to) | 3579-3586 |
| Number of pages | 8 |
| Journal | Journal of Materials Chemistry B |
| Volume | 11 |
| Issue number | 16 |
| Early online date | 4 Apr 2023 |
| Publication status | Published - 2023 |
Abstract
Shape memory polymers (SMPs) show great potential in biomedical fields. However, most of the SMPs are not suitable for use in the human body due to their deleteriousness and harsh actuation conditions. It is important to diversify SMPs that could be actuated in the human body environment. Herein, we construct a reversible shape-memory polydimethylsiloxane (RSMPDMS) based on a feasible strategy by deposing the PDMS-salt layer with dynamic micro-creases on the pure PDMS layer. Testing results reveal that it equips with self-expanding, bio-compatibility, drug storage-release and good mechanical toughness. The RSMPDMS could be variously shaped, such as ring, coil, and spiral. The prepared samples present efficient deformation-recovery with high mechanical stability during water absorption-desorption cycles. Moreover, the RSMPDMS is confirmed biocompatible by cell viability analysis and cell fluorescent labeling method, accompanied with efficient drug storage-release. The novel-designed RSMPDMS may contribute to the development of new shape memory biomedical materials.
ASJC Scopus subject areas
- Chemistry(all)
- Engineering(all)
- Biomedical Engineering
- Materials Science(all)
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In: Journal of Materials Chemistry B, Vol. 11, No. 16, 2023, p. 3579-3586.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Water-actuated reversible shape-memory polydimethylsiloxane for potential biomedical applications
AU - Sha, Wenjing
AU - Zhao, Junge
AU - Zhou, Yannong
AU - Xia, Jiangnan
AU - Yuan, Ming
AU - Zhang, Ningning
AU - Zhao, Huaixia
AU - Wang, Yangxin
N1 - Funding Information: The work was financially supported by the National Natural Science Foundation of China under award number 21704012, Natural Science Foundation of Jiangsu Higher Education Institutions of China under award number 21KJB430029, Startup Fund for Scientific Research from Nanjing Tech University and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
PY - 2023
Y1 - 2023
N2 - Shape memory polymers (SMPs) show great potential in biomedical fields. However, most of the SMPs are not suitable for use in the human body due to their deleteriousness and harsh actuation conditions. It is important to diversify SMPs that could be actuated in the human body environment. Herein, we construct a reversible shape-memory polydimethylsiloxane (RSMPDMS) based on a feasible strategy by deposing the PDMS-salt layer with dynamic micro-creases on the pure PDMS layer. Testing results reveal that it equips with self-expanding, bio-compatibility, drug storage-release and good mechanical toughness. The RSMPDMS could be variously shaped, such as ring, coil, and spiral. The prepared samples present efficient deformation-recovery with high mechanical stability during water absorption-desorption cycles. Moreover, the RSMPDMS is confirmed biocompatible by cell viability analysis and cell fluorescent labeling method, accompanied with efficient drug storage-release. The novel-designed RSMPDMS may contribute to the development of new shape memory biomedical materials.
AB - Shape memory polymers (SMPs) show great potential in biomedical fields. However, most of the SMPs are not suitable for use in the human body due to their deleteriousness and harsh actuation conditions. It is important to diversify SMPs that could be actuated in the human body environment. Herein, we construct a reversible shape-memory polydimethylsiloxane (RSMPDMS) based on a feasible strategy by deposing the PDMS-salt layer with dynamic micro-creases on the pure PDMS layer. Testing results reveal that it equips with self-expanding, bio-compatibility, drug storage-release and good mechanical toughness. The RSMPDMS could be variously shaped, such as ring, coil, and spiral. The prepared samples present efficient deformation-recovery with high mechanical stability during water absorption-desorption cycles. Moreover, the RSMPDMS is confirmed biocompatible by cell viability analysis and cell fluorescent labeling method, accompanied with efficient drug storage-release. The novel-designed RSMPDMS may contribute to the development of new shape memory biomedical materials.
UR - http://www.scopus.com/inward/record.url?scp=85153477567&partnerID=8YFLogxK
U2 - 10.1039/d2tb02503e
DO - 10.1039/d2tb02503e
M3 - Article
C2 - 37057629
AN - SCOPUS:85153477567
VL - 11
SP - 3579
EP - 3586
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
SN - 2050-750X
IS - 16
ER -