Details
| Original language | English |
|---|---|
| Article number | 3 |
| Journal | NUTRIENTS |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - 21 Dec 2017 |
Abstract
Keywords
- Dietary patterns, Vitamin E, α-tocopherol, γ-tocopherol, Eating, Cross-Sectional Studies, Diet Surveys, Humans, Middle Aged, Spectrometry, Fluorescence, Feeding Behavior, Linear Models, Male, Chromatography, High Pressure Liquid, gamma-Tocopherol/blood, alpha-Tocopherol/blood, Biomarkers/blood, Female, Aged, Nutritional Status, Lipids/blood, Principal Component Analysis, Germany
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Food Science
- Nursing(all)
- Nutrition and Dietetics
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In: NUTRIENTS, Vol. 10, No. 1, 3, 21.12.2017.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Vitamin E (α-and γ-tocopherol) levels in the community: Distribution, clinical and biochemical correlates, and association with dietary patterns
AU - Waniek, S.
AU - Di Giuseppe, R.
AU - Esatbeyoglu, T.
AU - Plachta-Danielzik, S.
AU - Ratjen, I.
AU - Jacobs, G.
AU - Nöthlings, U.
AU - Koch, M.
AU - Schlesinger, S.
AU - Rimbach, G.
AU - Lieb, W.
N1 - Funding information: Acknowledgments: Manja Koch is recipient of a Postdoctoral Research Fellowship from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG, KO 5187/1-1). RdG is supported by the Deutsche Forschungsgemeinschaft Excellence Cluster “Inflammation Interfaces” (grants EXC306 and EXC306/2). The PopGen 2.0 Network is supported by the German Federal Ministry of Education and Research (grant 01GR0468 and 01EY1103). The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
PY - 2017/12/21
Y1 - 2017/12/21
N2 - Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a priori and a posteriori derived dietary patterns. Plasma α- and γ-tocopherol concentrations were measured using high performance liquid chromatography (HPLC) with fluorescence detection in 641 individuals (mean-age: 61 years; 40.6% women). Correlates of both markers were determined using linear regression with backward selection. Using a validated food-frequency questionnaire (FFQ), an a priori defined vitamin E-rich dietary pattern was constructed, and three a posteriori derived dietary patterns were identified by principal component analysis. Each pattern was related to α- and γ-tocopherol levels using linear regression. Median concentrations of α- and γ-tocopherol were 31.54 μmol/L and 1.35 µmol/L, respectively. 57.6% of participants had α-tocopherol levels >30 µmol/L. Triglycerides, high density lipoprotein (HDL)- and low density lipoprotein (LDL)-cholesterol, and vitamin E supplementation were identified as correlates of vitamin E levels. After excluding supplement users, a dietary pattern rich in meat, bread, fats, potatoes, and sugar/confectionery was inversely related to α-tocopherol levels (β, -0.032, SE = 0.016; p = 0.047). Prospective studies are warranted to evaluate the actual impact of the reported findings in terms of nutrition and health outcomes.
AB - Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed the distribution of both α- and γ-tocopherol levels, identified their clinical and biochemical correlates, and assessed their relationships with a priori and a posteriori derived dietary patterns. Plasma α- and γ-tocopherol concentrations were measured using high performance liquid chromatography (HPLC) with fluorescence detection in 641 individuals (mean-age: 61 years; 40.6% women). Correlates of both markers were determined using linear regression with backward selection. Using a validated food-frequency questionnaire (FFQ), an a priori defined vitamin E-rich dietary pattern was constructed, and three a posteriori derived dietary patterns were identified by principal component analysis. Each pattern was related to α- and γ-tocopherol levels using linear regression. Median concentrations of α- and γ-tocopherol were 31.54 μmol/L and 1.35 µmol/L, respectively. 57.6% of participants had α-tocopherol levels >30 µmol/L. Triglycerides, high density lipoprotein (HDL)- and low density lipoprotein (LDL)-cholesterol, and vitamin E supplementation were identified as correlates of vitamin E levels. After excluding supplement users, a dietary pattern rich in meat, bread, fats, potatoes, and sugar/confectionery was inversely related to α-tocopherol levels (β, -0.032, SE = 0.016; p = 0.047). Prospective studies are warranted to evaluate the actual impact of the reported findings in terms of nutrition and health outcomes.
KW - Dietary patterns
KW - Vitamin E
KW - α-tocopherol
KW - γ-tocopherol
KW - Eating
KW - Cross-Sectional Studies
KW - Diet Surveys
KW - Humans
KW - Middle Aged
KW - Spectrometry, Fluorescence
KW - Feeding Behavior
KW - Linear Models
KW - Male
KW - Chromatography, High Pressure Liquid
KW - gamma-Tocopherol/blood
KW - alpha-Tocopherol/blood
KW - Biomarkers/blood
KW - Female
KW - Aged
KW - Nutritional Status
KW - Lipids/blood
KW - Principal Component Analysis
KW - Germany
UR - http://www.scopus.com/inward/record.url?scp=85039754994&partnerID=8YFLogxK
U2 - 10.3390/nu10010003
DO - 10.3390/nu10010003
M3 - Article
C2 - 29267223
VL - 10
JO - NUTRIENTS
JF - NUTRIENTS
SN - 2072-6643
IS - 1
M1 - 3
ER -