Details
| Original language | English |
|---|---|
| Pages (from-to) | 344-360 |
| Number of pages | 17 |
| Journal | Engineering in life sciences |
| Volume | 22 |
| Issue number | 3-4 |
| Early online date | 7 Jan 2022 |
| Publication status | Published - Mar 2022 |
Abstract
Conventional synthetic vascular grafts require ongoing anticoagulation, and autologous venous grafts are often not available in elderly patients. This review highlights the development of bioartificial vessels replacing brain-dead donor- or animal-deriving vessels with ongoing immune reactivity. The vision for such bio-hybrids exists in a combination of biodegradable scaffolds and seeding with immune-neutral cells, and here different cells sources such as autologous progenitor cells or stem cells are relevant. This kind of in situ tissue engineering depends on a suitable bioreactor system with elaborate monitoring systems, three-dimensional (3D) visualization and a potential of cell conditioning into the direction of the targeted vascular cell phenotype. Necessary bioreactor tools for dynamic and pulsatile cultivation are described. In addition, a concept for design of vasa vasorum is outlined, that is needed for sustainable nutrition of the wall structure in large caliber vessels. For scaffold design and cell adhesion additives, different materials and technologies are discussed. 3D printing is introduced as a relatively new field with promising prospects, for example, to create complex geometries or micro-structured surfaces for optimal cell adhesion and ingrowth in a standardized and custom designed procedure. Summarizing, a bio-hybrid vascular prosthesis from a controlled biotechnological process is thus coming more and more into view. It has the potential to withstand strict approval requirements applied for advanced therapy medicinal products.
Keywords
- 3D printing, bioreactor design, tissue engineering, vascular implants
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Environmental Science(all)
- Environmental Engineering
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In: Engineering in life sciences, Vol. 22, No. 3-4, 03.2022, p. 344-360.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Vascular implants – new aspects for in situ tissue engineering
AU - Blume, Cornelia
AU - Kraus, Xenia
AU - Heene, Sebastian
AU - Loewner, Sebastian
AU - Stanislawski, Nils
AU - Cholewa, Fabian
AU - Blume, Holger
N1 - Funding Information: Exemplary results reported here were funded by the Deutsche Forschungsgemeinschaft (DFG, Grant No 388094931) and within the framework of SMART BIOTECS, an alliance between the Technische Universitaet Braunschweig and the Leibniz University Hannover, supported by the Minister of Economy and Culture (MWK) of Lower Saxony.
PY - 2022/3
Y1 - 2022/3
N2 - Conventional synthetic vascular grafts require ongoing anticoagulation, and autologous venous grafts are often not available in elderly patients. This review highlights the development of bioartificial vessels replacing brain-dead donor- or animal-deriving vessels with ongoing immune reactivity. The vision for such bio-hybrids exists in a combination of biodegradable scaffolds and seeding with immune-neutral cells, and here different cells sources such as autologous progenitor cells or stem cells are relevant. This kind of in situ tissue engineering depends on a suitable bioreactor system with elaborate monitoring systems, three-dimensional (3D) visualization and a potential of cell conditioning into the direction of the targeted vascular cell phenotype. Necessary bioreactor tools for dynamic and pulsatile cultivation are described. In addition, a concept for design of vasa vasorum is outlined, that is needed for sustainable nutrition of the wall structure in large caliber vessels. For scaffold design and cell adhesion additives, different materials and technologies are discussed. 3D printing is introduced as a relatively new field with promising prospects, for example, to create complex geometries or micro-structured surfaces for optimal cell adhesion and ingrowth in a standardized and custom designed procedure. Summarizing, a bio-hybrid vascular prosthesis from a controlled biotechnological process is thus coming more and more into view. It has the potential to withstand strict approval requirements applied for advanced therapy medicinal products.
AB - Conventional synthetic vascular grafts require ongoing anticoagulation, and autologous venous grafts are often not available in elderly patients. This review highlights the development of bioartificial vessels replacing brain-dead donor- or animal-deriving vessels with ongoing immune reactivity. The vision for such bio-hybrids exists in a combination of biodegradable scaffolds and seeding with immune-neutral cells, and here different cells sources such as autologous progenitor cells or stem cells are relevant. This kind of in situ tissue engineering depends on a suitable bioreactor system with elaborate monitoring systems, three-dimensional (3D) visualization and a potential of cell conditioning into the direction of the targeted vascular cell phenotype. Necessary bioreactor tools for dynamic and pulsatile cultivation are described. In addition, a concept for design of vasa vasorum is outlined, that is needed for sustainable nutrition of the wall structure in large caliber vessels. For scaffold design and cell adhesion additives, different materials and technologies are discussed. 3D printing is introduced as a relatively new field with promising prospects, for example, to create complex geometries or micro-structured surfaces for optimal cell adhesion and ingrowth in a standardized and custom designed procedure. Summarizing, a bio-hybrid vascular prosthesis from a controlled biotechnological process is thus coming more and more into view. It has the potential to withstand strict approval requirements applied for advanced therapy medicinal products.
KW - 3D printing
KW - bioreactor design
KW - tissue engineering
KW - vascular implants
UR - http://www.scopus.com/inward/record.url?scp=85122519878&partnerID=8YFLogxK
U2 - 10.1002/elsc.202100100
DO - 10.1002/elsc.202100100
M3 - Review article
AN - SCOPUS:85122519878
VL - 22
SP - 344
EP - 360
JO - Engineering in life sciences
JF - Engineering in life sciences
SN - 1618-0240
IS - 3-4
ER -