Details
| Original language | English |
|---|---|
| Article number | 1600818 |
| Journal | Advanced healthcare materials |
| Volume | 6 |
| Issue number | 2 |
| Publication status | Published - 25 Jan 2017 |
Abstract
Metal-organic frameworks (MOFs) are promising platforms for the synthesis of nanoparticles for diverse medical applications. Their fundamental design principles allow for significant control of the framework architecture and pore chemistry, enabling directed functionalization for nanomedical applications. However, before applying novel nanomaterials to patients, it is imperative to understand their potential health risks. In this study, the nanosafety of different MOF nanoparticles is analyzed comprehensively for diverse medical applications. The authors first evaluate the effects of MOFs on human endothelial and mouse lung cells, which constitute a first line of defense upon systemic blood-mediated and local lung-specific applications of nanoparticles. Second, we validated these MOFs for multifunctional surface coatings of dental implants using human gingiva fibroblasts. Moreover, biocompatibility of MOFs is assessed for surface coating of nerve guidance tubes using human Schwann cells and rat dorsal root ganglion cultures. The main finding of this study is that the nanosafety and principal suitability of our MOF nanoparticles as novel agents for drug delivery and implant coatings strongly varies with the effector cell type. We conclude that it is therefore necessary to carefully evaluate the nanosafety of MOF nanomaterials with respect to their particular medical application and their interacting primary cell types, respectively.
Keywords
- drug delivery, metal-organic frameworks, nanomedicine, nanoparticles, nanosafety
ASJC Scopus subject areas
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
Sustainable Development Goals
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Advanced healthcare materials, Vol. 6, No. 2, 1600818, 25.01.2017.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications
AU - Wuttke, Stefan
AU - Zimpel, Andreas
AU - Bein, Thomas
AU - Braig, Simone
AU - Stoiber, Katharina
AU - Vollmar, Angelika
AU - Müller, Dominik
AU - Haastert-Talini, Kirsten
AU - Schaeske, Jörn
AU - Stiesch, Meike
AU - Zahn, Gesa
AU - Mohmeyer, Alexander
AU - Behrens, Peter
AU - Eickelberg, Oliver
AU - Bölükbas, Deniz A.
AU - Meiners, Silke
N1 - Funding Information: The authors from Munich are grateful for financial support from the Deutsche Forschungsgemeinschaft (DFG), the Excellence Cluster Nanosystems Initiative Munich (NIM), and the Center for NanoScience Munich (CeNS). In detail: D.A.B., A.V., and K.S. were funded by the NIM cluster at the LMU Munich, S.M. was funded by the Helmholtz Zentrum München; T.B. acknowledges support from the SFB 1032, NIM, and CeNS, and S.W. acknowledges support through the DFG-project WU 622/4-1 and CeNS. M.S. and P.B. acknowledge support from the State of Lower Saxony and the Volkswagen foundation through the research initiative BIOFABRICATION for Niedersächsisches Zentrum für Biomedizintechnik, Implantatforschung und Entwicklung (NIFE). The authors thank Dr. Sandra Wrobel and Silvana Taubeler-Gerling, both Institute of Neuroanatomy Medizinische Hochschule Hannover, and Christina Lukas and Tobias Stöger from the CPC Munich for excellent technical support and scientific input, respectively.
PY - 2017/1/25
Y1 - 2017/1/25
N2 - Metal-organic frameworks (MOFs) are promising platforms for the synthesis of nanoparticles for diverse medical applications. Their fundamental design principles allow for significant control of the framework architecture and pore chemistry, enabling directed functionalization for nanomedical applications. However, before applying novel nanomaterials to patients, it is imperative to understand their potential health risks. In this study, the nanosafety of different MOF nanoparticles is analyzed comprehensively for diverse medical applications. The authors first evaluate the effects of MOFs on human endothelial and mouse lung cells, which constitute a first line of defense upon systemic blood-mediated and local lung-specific applications of nanoparticles. Second, we validated these MOFs for multifunctional surface coatings of dental implants using human gingiva fibroblasts. Moreover, biocompatibility of MOFs is assessed for surface coating of nerve guidance tubes using human Schwann cells and rat dorsal root ganglion cultures. The main finding of this study is that the nanosafety and principal suitability of our MOF nanoparticles as novel agents for drug delivery and implant coatings strongly varies with the effector cell type. We conclude that it is therefore necessary to carefully evaluate the nanosafety of MOF nanomaterials with respect to their particular medical application and their interacting primary cell types, respectively.
AB - Metal-organic frameworks (MOFs) are promising platforms for the synthesis of nanoparticles for diverse medical applications. Their fundamental design principles allow for significant control of the framework architecture and pore chemistry, enabling directed functionalization for nanomedical applications. However, before applying novel nanomaterials to patients, it is imperative to understand their potential health risks. In this study, the nanosafety of different MOF nanoparticles is analyzed comprehensively for diverse medical applications. The authors first evaluate the effects of MOFs on human endothelial and mouse lung cells, which constitute a first line of defense upon systemic blood-mediated and local lung-specific applications of nanoparticles. Second, we validated these MOFs for multifunctional surface coatings of dental implants using human gingiva fibroblasts. Moreover, biocompatibility of MOFs is assessed for surface coating of nerve guidance tubes using human Schwann cells and rat dorsal root ganglion cultures. The main finding of this study is that the nanosafety and principal suitability of our MOF nanoparticles as novel agents for drug delivery and implant coatings strongly varies with the effector cell type. We conclude that it is therefore necessary to carefully evaluate the nanosafety of MOF nanomaterials with respect to their particular medical application and their interacting primary cell types, respectively.
KW - drug delivery
KW - metal-organic frameworks
KW - nanomedicine
KW - nanoparticles
KW - nanosafety
UR - http://www.scopus.com/inward/record.url?scp=85000366247&partnerID=8YFLogxK
U2 - 10.1002/adhm.201600818
DO - 10.1002/adhm.201600818
M3 - Article
C2 - 27863166
AN - SCOPUS:85000366247
VL - 6
JO - Advanced healthcare materials
JF - Advanced healthcare materials
SN - 2192-2640
IS - 2
M1 - 1600818
ER -