Details
| Original language | English |
|---|---|
| Pages (from-to) | 523-530 |
| Number of pages | 8 |
| Journal | Infection and drug resistance |
| Volume | 11 |
| Publication status | Published - 11 Apr 2018 |
Abstract
Collective antibiotic drug resistance is a global threat, especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as a challenging barrier that prevents a sufficient antibiotic effect to be attained at low doses of the antibiotic. The Gram-negative bacterial cell envelope comprises an outer membrane that delimits the periplasm from the exterior milieu. The crucial mechanisms of antibiotic entry via outer membrane includes general diffusion porins (Omps) responsible for hydrophilic antibiotics and lipid-mediated pathway for hydrophobic antibiotics. The protein and lipid arrangements of the outer membrane have had a strong impact on the understanding of bacteria and their resistance to many types of antibiotics. Thus, one of the current challenges is effective interpretation at the molecular basis of the outer membrane permeability. This review attempts to develop a state of knowledge pertinent to Omps and their effective role in solute influx. Moreover, it aims toward further understanding and exploration of prospects to improve our knowledge of physicochemical limitations that direct the translocation of antibiotics via bacterial outer membrane.
Keywords
- Antibiotics, Drug-resistance, Gram-negative bacteria, Influx, Membrane permeability, Outer membrane proteins, Porins
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology
- Medicine(all)
- Infectious Diseases
- Medicine(all)
- Pharmacology (medical)
Sustainable Development Goals
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Infection and drug resistance, Vol. 11, 11.04.2018, p. 523-530.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Understanding antibiotic resistance via outer membrane permeability
AU - Ghai, Ishan
AU - Ghai, Shashank
N1 - Funding Information: The publication of this article was funded by the Open Access fund of Leibniz Universität Hannover. The authors sincerely thank their research groups for their support.
PY - 2018/4/11
Y1 - 2018/4/11
N2 - Collective antibiotic drug resistance is a global threat, especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as a challenging barrier that prevents a sufficient antibiotic effect to be attained at low doses of the antibiotic. The Gram-negative bacterial cell envelope comprises an outer membrane that delimits the periplasm from the exterior milieu. The crucial mechanisms of antibiotic entry via outer membrane includes general diffusion porins (Omps) responsible for hydrophilic antibiotics and lipid-mediated pathway for hydrophobic antibiotics. The protein and lipid arrangements of the outer membrane have had a strong impact on the understanding of bacteria and their resistance to many types of antibiotics. Thus, one of the current challenges is effective interpretation at the molecular basis of the outer membrane permeability. This review attempts to develop a state of knowledge pertinent to Omps and their effective role in solute influx. Moreover, it aims toward further understanding and exploration of prospects to improve our knowledge of physicochemical limitations that direct the translocation of antibiotics via bacterial outer membrane.
AB - Collective antibiotic drug resistance is a global threat, especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as a challenging barrier that prevents a sufficient antibiotic effect to be attained at low doses of the antibiotic. The Gram-negative bacterial cell envelope comprises an outer membrane that delimits the periplasm from the exterior milieu. The crucial mechanisms of antibiotic entry via outer membrane includes general diffusion porins (Omps) responsible for hydrophilic antibiotics and lipid-mediated pathway for hydrophobic antibiotics. The protein and lipid arrangements of the outer membrane have had a strong impact on the understanding of bacteria and their resistance to many types of antibiotics. Thus, one of the current challenges is effective interpretation at the molecular basis of the outer membrane permeability. This review attempts to develop a state of knowledge pertinent to Omps and their effective role in solute influx. Moreover, it aims toward further understanding and exploration of prospects to improve our knowledge of physicochemical limitations that direct the translocation of antibiotics via bacterial outer membrane.
KW - Antibiotics
KW - Drug-resistance
KW - Gram-negative bacteria
KW - Influx
KW - Membrane permeability
KW - Outer membrane proteins
KW - Porins
UR - http://www.scopus.com/inward/record.url?scp=85046358213&partnerID=8YFLogxK
U2 - 10.2147/IDR.S156995
DO - 10.2147/IDR.S156995
M3 - Article
AN - SCOPUS:85046358213
VL - 11
SP - 523
EP - 530
JO - Infection and drug resistance
JF - Infection and drug resistance
SN - 1178-6973
ER -