Details
| Original language | English |
|---|---|
| Pages (from-to) | 6229-6246 |
| Number of pages | 18 |
| Journal | Analytical and Bioanalytical Chemistry |
| Volume | 411 |
| Issue number | 24 |
| Early online date | 8 Apr 2019 |
| Publication status | Published - Sept 2019 |
Abstract
With recent advances in ionization sources and instrumentation, ion mobility spectrometers (IMS) have transformed from a detector for chemical warfare agents and explosives to a widely used tool in analytical and bioanalytical applications. This increasing measurement task complexity requires higher and higher analytical performance and especially ultra-high resolution. In this review, we will discuss the currently used ion mobility spectrometers able to reach such ultra-high resolution, defined here as a resolving power greater than 200. These instruments are drift tube IMS, traveling wave IMS, trapped IMS, and field asymmetric or differential IMS. The basic operating principles and the resulting effects of experimental parameters on resolving power are explained and compared between the different instruments. This allows understanding the current limitations of resolving power and how ion mobility spectrometers may progress in the future. Graphical abstract.
Keywords
- Differential IMS, Drift tube, Field asymmetric IMS, Ion mobility spectrometry (IMS), Trapped IMS, Traveling wave
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
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In: Analytical and Bioanalytical Chemistry, Vol. 411, No. 24, 09.2019, p. 6229-6246.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Ultra-high-resolution ion mobility spectrometry
T2 - current instrumentation, limitations, and future developments
AU - Kirk, Ansgar T.
AU - Bohnhorst, Alexander
AU - Raddatz, Christian-Robert
AU - Allers, Maria
AU - Zimmermann, Stefan
N1 - Funding information: This work is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—ZI 1288/4–1 and ZI 1288/7-1.
PY - 2019/9
Y1 - 2019/9
N2 - With recent advances in ionization sources and instrumentation, ion mobility spectrometers (IMS) have transformed from a detector for chemical warfare agents and explosives to a widely used tool in analytical and bioanalytical applications. This increasing measurement task complexity requires higher and higher analytical performance and especially ultra-high resolution. In this review, we will discuss the currently used ion mobility spectrometers able to reach such ultra-high resolution, defined here as a resolving power greater than 200. These instruments are drift tube IMS, traveling wave IMS, trapped IMS, and field asymmetric or differential IMS. The basic operating principles and the resulting effects of experimental parameters on resolving power are explained and compared between the different instruments. This allows understanding the current limitations of resolving power and how ion mobility spectrometers may progress in the future. Graphical abstract.
AB - With recent advances in ionization sources and instrumentation, ion mobility spectrometers (IMS) have transformed from a detector for chemical warfare agents and explosives to a widely used tool in analytical and bioanalytical applications. This increasing measurement task complexity requires higher and higher analytical performance and especially ultra-high resolution. In this review, we will discuss the currently used ion mobility spectrometers able to reach such ultra-high resolution, defined here as a resolving power greater than 200. These instruments are drift tube IMS, traveling wave IMS, trapped IMS, and field asymmetric or differential IMS. The basic operating principles and the resulting effects of experimental parameters on resolving power are explained and compared between the different instruments. This allows understanding the current limitations of resolving power and how ion mobility spectrometers may progress in the future. Graphical abstract.
KW - Differential IMS
KW - Drift tube
KW - Field asymmetric IMS
KW - Ion mobility spectrometry (IMS)
KW - Trapped IMS
KW - Traveling wave
UR - http://www.scopus.com/inward/record.url?scp=85064476073&partnerID=8YFLogxK
U2 - 10.15488/10986
DO - 10.15488/10986
M3 - Review article
C2 - 30957205
AN - SCOPUS:85064476073
VL - 411
SP - 6229
EP - 6246
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
SN - 1618-2642
IS - 24
ER -