Details
| Original language | English |
|---|---|
| Article number | 029014 |
| Number of pages | 1 |
| Journal | BIOINTERPHASES |
| Volume | 9 |
| Issue number | 2 |
| Publication status | Published - 28 Apr 2014 |
| Externally published | Yes |
Abstract
Two-photon polymerization is a technique that involves simultaneous absorption of two photons from a femtosecond laser for selective polymerization of a photosensitive material. In this study, two-photon polymerization was used for layer-by-layer fabrication of 3-D scaffolds composed of an inorganic-organic zirconium oxide hybrid material. Four types of scaffold microarchitectures were created, which exhibit layers of parallel line features at various orientations as well as pores between the line features. Long-term cell culture studies involving human bone marrow stromal cells were conducted using these 3-D scaffolds. Cellular adhesion and proliferation were demonstrated on all of the scaffold types; tissuelike structure was shown to span the pores. This study indicates that two-photon polymerization may be used to create microstructured scaffolds out of an inorganic-organic zirconium oxide hybrid material for use in 3-D tissue culture systems.
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Materials Science(all)
- Biomaterials
- Materials Science(all)
- General Materials Science
- Biochemistry, Genetics and Molecular Biology(all)
- General Biochemistry,Genetics and Molecular Biology
- Physics and Astronomy(all)
- General Physics and Astronomy
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In: BIOINTERPHASES, Vol. 9, No. 2, 029014, 28.04.2014.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Two-photon polymerization of 3-D zirconium oxide hybrid scaffolds for long-term stem cell growth
AU - Skoog, Shelby A.
AU - Nguyen, Alexander K.
AU - Kumar, Girish
AU - Zheng, Jiwen
AU - Goering, Peter L.
AU - Koroleva, Anastasia
AU - Chichkov, Boris N.
AU - Narayan, Roger J.
PY - 2014/4/28
Y1 - 2014/4/28
N2 - Two-photon polymerization is a technique that involves simultaneous absorption of two photons from a femtosecond laser for selective polymerization of a photosensitive material. In this study, two-photon polymerization was used for layer-by-layer fabrication of 3-D scaffolds composed of an inorganic-organic zirconium oxide hybrid material. Four types of scaffold microarchitectures were created, which exhibit layers of parallel line features at various orientations as well as pores between the line features. Long-term cell culture studies involving human bone marrow stromal cells were conducted using these 3-D scaffolds. Cellular adhesion and proliferation were demonstrated on all of the scaffold types; tissuelike structure was shown to span the pores. This study indicates that two-photon polymerization may be used to create microstructured scaffolds out of an inorganic-organic zirconium oxide hybrid material for use in 3-D tissue culture systems.
AB - Two-photon polymerization is a technique that involves simultaneous absorption of two photons from a femtosecond laser for selective polymerization of a photosensitive material. In this study, two-photon polymerization was used for layer-by-layer fabrication of 3-D scaffolds composed of an inorganic-organic zirconium oxide hybrid material. Four types of scaffold microarchitectures were created, which exhibit layers of parallel line features at various orientations as well as pores between the line features. Long-term cell culture studies involving human bone marrow stromal cells were conducted using these 3-D scaffolds. Cellular adhesion and proliferation were demonstrated on all of the scaffold types; tissuelike structure was shown to span the pores. This study indicates that two-photon polymerization may be used to create microstructured scaffolds out of an inorganic-organic zirconium oxide hybrid material for use in 3-D tissue culture systems.
UR - http://www.scopus.com/inward/record.url?scp=84918525170&partnerID=8YFLogxK
U2 - 10.1116/1.4873688
DO - 10.1116/1.4873688
M3 - Article
C2 - 24985218
AN - SCOPUS:84918525170
VL - 9
JO - BIOINTERPHASES
JF - BIOINTERPHASES
SN - 1559-4106
IS - 2
M1 - 029014
ER -