Details
| Original language | English |
|---|---|
| Pages (from-to) | 365-377 |
| Number of pages | 13 |
| Journal | Molecular Biotechnology |
| Volume | 66 |
| Issue number | 3 |
| Early online date | 14 Dec 2022 |
| Publication status | Published - Mar 2024 |
Abstract
Thanks to recent and continuing technological innovations, modern microfluidic systems are increasingly offering researchers working across all fields of biotechnology exciting new possibilities (especially with respect to facilitating high throughput analysis, portability, and parallelization). The advantages offered by microfluidic devices—namely, the substantially lowered chemical and sample consumption they require, the increased energy and mass transfer they offer, and their comparatively small size—can potentially be leveraged in every sub-field of biotechnology. However, to date, most of the reported devices have been deployed in furtherance of healthcare, pharmaceutical, and/or industrial applications. In this review, we consider examples of microfluidic and miniaturized systems across biotechnology sub-fields. In this context, we point out the advantages of microfluidics for various applications and highlight the common features of devices and the potential for transferability to other application areas. This will provide incentives for increased collaboration between researchers from different disciplines in the field of biotechnology.
Keywords
- Biochemical engineering, Industrial biotechnology, Lab-on-a-chip, Medical biotechnology, Microfluidic screening, Microfluidics, Nanofluidics, Organ-on-a-chip, Point-of-care, Point-of-use
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
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In: Molecular Biotechnology, Vol. 66, No. 3, 03.2024, p. 365-377.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Towards Small Scale
T2 - Overview and Applications of Microfluidics in Biotechnology
AU - Enders, Anton
AU - Grünberger, Alexander
AU - Bahnemann, Janina
N1 - Funding Information: This research was supported by the NIH grants P01AG043352 and R01AG046860. Open Access funding enabled and organized by Projekt DEAL. Funding was provided by German Research Foundation (DFG) (Grant No. 346772917 Emmy Noether Programme).
PY - 2024/3
Y1 - 2024/3
N2 - Thanks to recent and continuing technological innovations, modern microfluidic systems are increasingly offering researchers working across all fields of biotechnology exciting new possibilities (especially with respect to facilitating high throughput analysis, portability, and parallelization). The advantages offered by microfluidic devices—namely, the substantially lowered chemical and sample consumption they require, the increased energy and mass transfer they offer, and their comparatively small size—can potentially be leveraged in every sub-field of biotechnology. However, to date, most of the reported devices have been deployed in furtherance of healthcare, pharmaceutical, and/or industrial applications. In this review, we consider examples of microfluidic and miniaturized systems across biotechnology sub-fields. In this context, we point out the advantages of microfluidics for various applications and highlight the common features of devices and the potential for transferability to other application areas. This will provide incentives for increased collaboration between researchers from different disciplines in the field of biotechnology.
AB - Thanks to recent and continuing technological innovations, modern microfluidic systems are increasingly offering researchers working across all fields of biotechnology exciting new possibilities (especially with respect to facilitating high throughput analysis, portability, and parallelization). The advantages offered by microfluidic devices—namely, the substantially lowered chemical and sample consumption they require, the increased energy and mass transfer they offer, and their comparatively small size—can potentially be leveraged in every sub-field of biotechnology. However, to date, most of the reported devices have been deployed in furtherance of healthcare, pharmaceutical, and/or industrial applications. In this review, we consider examples of microfluidic and miniaturized systems across biotechnology sub-fields. In this context, we point out the advantages of microfluidics for various applications and highlight the common features of devices and the potential for transferability to other application areas. This will provide incentives for increased collaboration between researchers from different disciplines in the field of biotechnology.
KW - Biochemical engineering
KW - Industrial biotechnology
KW - Lab-on-a-chip
KW - Medical biotechnology
KW - Microfluidic screening
KW - Microfluidics
KW - Nanofluidics
KW - Organ-on-a-chip
KW - Point-of-care
KW - Point-of-use
UR - http://www.scopus.com/inward/record.url?scp=85143806617&partnerID=8YFLogxK
U2 - 10.1007/s12033-022-00626-6
DO - 10.1007/s12033-022-00626-6
M3 - Review article
AN - SCOPUS:85143806617
VL - 66
SP - 365
EP - 377
JO - Molecular Biotechnology
JF - Molecular Biotechnology
SN - 1073-6085
IS - 3
ER -