Details
| Original language | English |
|---|---|
| Pages (from-to) | 270-277 |
| Number of pages | 8 |
| Journal | Beilstein Journal of Organic Chemistry |
| Volume | 9 |
| Publication status | Published - 8 Feb 2013 |
Abstract
Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free "click" approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.
Keywords
- Click chemistry, Growth factor, Nitrenes, Plasma chemistry, Poly(4-methylpent-1-ene), Surface modification
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
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In: Beilstein Journal of Organic Chemistry, Vol. 9, 08.02.2013, p. 270-277.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Towards a biocompatible artificial lung
T2 - Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
AU - Möller, Lena
AU - Hess, Christian
AU - Paleček, Jiří
AU - Su, Yi
AU - Haverich, Axel
AU - Kirschning, Andreas
AU - Dräger, Gerald
PY - 2013/2/8
Y1 - 2013/2/8
N2 - Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free "click" approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.
AB - Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free "click" approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.
KW - Click chemistry
KW - Growth factor
KW - Nitrenes
KW - Plasma chemistry
KW - Poly(4-methylpent-1-ene)
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=84874637792&partnerID=8YFLogxK
U2 - 10.3762/bjoc.9.33
DO - 10.3762/bjoc.9.33
M3 - Article
AN - SCOPUS:84874637792
VL - 9
SP - 270
EP - 277
JO - Beilstein Journal of Organic Chemistry
JF - Beilstein Journal of Organic Chemistry
SN - 1860-5397
ER -