Details
| Original language | English |
|---|---|
| Pages (from-to) | 4364-4366 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 39 |
| Issue number | 23 |
| Publication status | Published - 4 Dec 2000 |
Abstract
The coupling of three fragmeats by a wittig olefination and a subsequent selective Heck reaction are the pivotal steps in the the first total synthesis of ratjadone (see picture), a cytotoxic as well as antibiotically effective polyketide. This synthesis enabled the elucidation of the absolute configuration of the natural product. In this way it should also be possible to synthesize structural analogues with which the various cellular processes mediated by ratjadone can be studied.
Keywords
- Heck reactions, Natural products, Palladium, Total synthesis
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
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In: Angewandte Chemie - International Edition, Vol. 39, No. 23, 04.12.2000, p. 4364-4366.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Total synthesis of (+)-ratjadone
AU - Christmann, Mathias
AU - Bhatt, Ulhas
AU - Quitschalle, Monika
AU - Claus, Eckhard
AU - Kalesse, Markus
PY - 2000/12/4
Y1 - 2000/12/4
N2 - The coupling of three fragmeats by a wittig olefination and a subsequent selective Heck reaction are the pivotal steps in the the first total synthesis of ratjadone (see picture), a cytotoxic as well as antibiotically effective polyketide. This synthesis enabled the elucidation of the absolute configuration of the natural product. In this way it should also be possible to synthesize structural analogues with which the various cellular processes mediated by ratjadone can be studied.
AB - The coupling of three fragmeats by a wittig olefination and a subsequent selective Heck reaction are the pivotal steps in the the first total synthesis of ratjadone (see picture), a cytotoxic as well as antibiotically effective polyketide. This synthesis enabled the elucidation of the absolute configuration of the natural product. In this way it should also be possible to synthesize structural analogues with which the various cellular processes mediated by ratjadone can be studied.
KW - Heck reactions
KW - Natural products
KW - Palladium
KW - Total synthesis
UR - http://www.scopus.com/inward/record.url?scp=0034605902&partnerID=8YFLogxK
U2 - 10.1002/1521-3773(20001201)39:23<4364::AID-ANIE4364>3.0.CO;2-G
DO - 10.1002/1521-3773(20001201)39:23<4364::AID-ANIE4364>3.0.CO;2-G
M3 - Article
AN - SCOPUS:0034605902
VL - 39
SP - 4364
EP - 4366
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 23
ER -