Details
| Original language | English |
|---|---|
| Pages (from-to) | 13610-13611 |
| Number of pages | 2 |
| Journal | Journal of the American Chemical Society |
| Volume | 132 |
| Issue number | 39 |
| Publication status | Published - 6 Oct 2010 |
Abstract
The first synthesis of the highly biologically active chivosazole F is described. It features an intramolecular Stille coupling for the macrolactone formation and thereby circumvents the problem of isomerization associated with the tetraene segment. Additionally, the synthesis confirms the structure which has been proposed based solely on a combination of NMR/computational methods and genetic analysis.
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemical Engineering(all)
- Colloid and Surface Chemistry
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In: Journal of the American Chemical Society, Vol. 132, No. 39, 06.10.2010, p. 13610-13611.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Total synthesis of chivosazole F
AU - Brodmann, Tobias
AU - Janssen, Dominic
AU - Kalesse, Markus
PY - 2010/10/6
Y1 - 2010/10/6
N2 - The first synthesis of the highly biologically active chivosazole F is described. It features an intramolecular Stille coupling for the macrolactone formation and thereby circumvents the problem of isomerization associated with the tetraene segment. Additionally, the synthesis confirms the structure which has been proposed based solely on a combination of NMR/computational methods and genetic analysis.
AB - The first synthesis of the highly biologically active chivosazole F is described. It features an intramolecular Stille coupling for the macrolactone formation and thereby circumvents the problem of isomerization associated with the tetraene segment. Additionally, the synthesis confirms the structure which has been proposed based solely on a combination of NMR/computational methods and genetic analysis.
UR - http://www.scopus.com/inward/record.url?scp=77957311255&partnerID=8YFLogxK
U2 - 10.1021/ja107290s
DO - 10.1021/ja107290s
M3 - Article
C2 - 20836495
AN - SCOPUS:77957311255
VL - 132
SP - 13610
EP - 13611
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 39
ER -