Details
| Translated title of the contribution | Totalsynthese von Carolacton, einem hochwirksamen Inhibitor von Biofilmen |
|---|---|
| Original language | English |
| Pages (from-to) | 1063-1066 |
| Number of pages | 4 |
| Journal | Angewandte Chemie |
| Volume | 51 |
| Issue number | 4 |
| Publication status | Published - 9 Dec 2011 |
Abstract
Metals are the key players in the synthesis of caralacton, a strong inhibitor of bacterial biofilms. The total synthesis is based on several metal-mediated key transformations such as the Ley and the Duthaler-Hafner aldol reactions, the Marshall reaction and Breit's substitution, as well as the Nozaki-Hiyama-Kishi and Negishi-Fu C-C coupling reactions.
Keywords
- biofilms, carolacton, Duthaler-Hafner aldol reaction, Marshall reaction, Negishi-Fu reaction, total synthesis
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: Angewandte Chemie , Vol. 51, No. 4, 09.12.2011, p. 1063-1066.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Total synthesis of carolacton, a highly potent biofilm inhibitor
AU - Schmidt, Thomas
AU - Kirschning, Andreas
PY - 2011/12/9
Y1 - 2011/12/9
N2 - Metals are the key players in the synthesis of caralacton, a strong inhibitor of bacterial biofilms. The total synthesis is based on several metal-mediated key transformations such as the Ley and the Duthaler-Hafner aldol reactions, the Marshall reaction and Breit's substitution, as well as the Nozaki-Hiyama-Kishi and Negishi-Fu C-C coupling reactions.
AB - Metals are the key players in the synthesis of caralacton, a strong inhibitor of bacterial biofilms. The total synthesis is based on several metal-mediated key transformations such as the Ley and the Duthaler-Hafner aldol reactions, the Marshall reaction and Breit's substitution, as well as the Nozaki-Hiyama-Kishi and Negishi-Fu C-C coupling reactions.
KW - biofilms
KW - carolacton
KW - Duthaler-Hafner aldol reaction
KW - Marshall reaction
KW - Negishi-Fu reaction
KW - total synthesis
UR - http://www.scopus.com/inward/record.url?scp=84856021728&partnerID=8YFLogxK
U2 - 10.1002/anie.201106762
DO - 10.1002/anie.201106762
M3 - Article
C2 - 22162345
AN - SCOPUS:84856021728
VL - 51
SP - 1063
EP - 1066
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 4
ER -