Total synthesis of carolacton, a highly potent biofilm inhibitor

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Translated title of the contributionTotalsynthese von Carolacton, einem hochwirksamen Inhibitor von Biofilmen
Original languageEnglish
Pages (from-to)1063-1066
Number of pages4
JournalAngewandte Chemie
Volume51
Issue number4
Publication statusPublished - 9 Dec 2011

Abstract

Metals are the key players in the synthesis of caralacton, a strong inhibitor of bacterial biofilms. The total synthesis is based on several metal-mediated key transformations such as the Ley and the Duthaler-Hafner aldol reactions, the Marshall reaction and Breit's substitution, as well as the Nozaki-Hiyama-Kishi and Negishi-Fu C-C coupling reactions.

Keywords

    biofilms, carolacton, Duthaler-Hafner aldol reaction, Marshall reaction, Negishi-Fu reaction, total synthesis

ASJC Scopus subject areas

Cite this

Total synthesis of carolacton, a highly potent biofilm inhibitor. / Schmidt, Thomas; Kirschning, Andreas.
In: Angewandte Chemie , Vol. 51, No. 4, 09.12.2011, p. 1063-1066.

Research output: Contribution to journalArticleResearchpeer review

Schmidt T, Kirschning A. Total synthesis of carolacton, a highly potent biofilm inhibitor. Angewandte Chemie . 2011 Dec 9;51(4):1063-1066. doi: 10.1002/anie.201106762, 10.1002/ange.201106762
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