Details
| Original language | English |
|---|---|
| Pages (from-to) | 3107-3109 |
| Number of pages | 3 |
| Journal | Organic letters |
| Volume | 3 |
| Issue number | 20 |
| Publication status | Published - 4 Oct 2001 |
Abstract
(equation presented) The enantioselective synthesis of callystatin A is descrided. The pivotal step in the synthesis is the stereoselective aldol reaction that generates the β-hydroxy ketone moiety. Utilizing the allylic strain within the ethyl ketone precursor, we were able to generate the all-syn configuration of callystatin A. For the construction of the two diene moieties, both a Heck coupling and a Wittig reaction were employed.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemistry(all)
- Organic Chemistry
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In: Organic letters, Vol. 3, No. 20, 04.10.2001, p. 3107-3109.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Total synthesis of (-)-callystatin A
AU - Kalesse, Markus
AU - Quitschalle, Monika
AU - Khandavalli, Chary P.
AU - Saeed, Aamer
PY - 2001/10/4
Y1 - 2001/10/4
N2 - (equation presented) The enantioselective synthesis of callystatin A is descrided. The pivotal step in the synthesis is the stereoselective aldol reaction that generates the β-hydroxy ketone moiety. Utilizing the allylic strain within the ethyl ketone precursor, we were able to generate the all-syn configuration of callystatin A. For the construction of the two diene moieties, both a Heck coupling and a Wittig reaction were employed.
AB - (equation presented) The enantioselective synthesis of callystatin A is descrided. The pivotal step in the synthesis is the stereoselective aldol reaction that generates the β-hydroxy ketone moiety. Utilizing the allylic strain within the ethyl ketone precursor, we were able to generate the all-syn configuration of callystatin A. For the construction of the two diene moieties, both a Heck coupling and a Wittig reaction were employed.
UR - http://www.scopus.com/inward/record.url?scp=0035807580&partnerID=8YFLogxK
U2 - 10.1021/ol016365l
DO - 10.1021/ol016365l
M3 - Article
C2 - 11574006
AN - SCOPUS:0035807580
VL - 3
SP - 3107
EP - 3109
JO - Organic letters
JF - Organic letters
SN - 1523-7060
IS - 20
ER -