Details
| Original language | English |
|---|---|
| Pages (from-to) | 13587-13590 |
| Number of pages | 4 |
| Journal | Chemical communications |
| Volume | 59 |
| Issue number | 91 |
| Early online date | 23 Oct 2023 |
| Publication status | Published - 2023 |
Abstract
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Materials Science(all)
- Ceramics and Composites
- Materials Science(all)
- Metals and Alloys
- Materials Science(all)
- Materials Chemistry
- Materials Science(all)
- Surfaces, Coatings and Films
- Chemistry(all)
- General Chemistry
- Chemical Engineering(all)
- Catalysis
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In: Chemical communications, Vol. 59, No. 91, 2023, p. 13587-13590.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Total biosynthesis of fungal tetraketide pyrones
AU - Sun, Yunlong
AU - Tian, Dongsong
AU - Kuhnert, Eric
AU - Le Goff, Geraldine
AU - Arcile, Guillaume
AU - Ouazzani, Jamal
AU - Cox, Russell J.
N1 - The China Scholarship Council is thanked for scholarships to Y. S. (201908360165) and D. T. (201706670001). This work was also funded by the Deutsche Forschungsgemeinschaft (DFG) priority program “Taxon-Omics: New Approaches for Discovering and Naming Biodiversity” (SPP 1991), specifically CO 1328/4-2 and CO 1328/4-1. Professor Thomas Ostenfeld Larsen (Danish Technical University) is thanked for the gift of Penicillium islandicum. The publication of this article was partially funded by the Open Access Fund of the Leibniz University of Hannover.
PY - 2023
Y1 - 2023
N2 - Fungal tetraketide pyrones possess important and potent bioactivities, but their detailed biosynthetic pathways are unknown and synthetic routes to their production are lengthy. Here we investigated the fungal pathways to the multiforisins and compounds related to islandic acid. Heterologous expression experiments yield high titres of these compounds and pathway intermediates. The results both elucidate the pathway and offer a platform for the total biosynthesis of this class of metabolites.
AB - Fungal tetraketide pyrones possess important and potent bioactivities, but their detailed biosynthetic pathways are unknown and synthetic routes to their production are lengthy. Here we investigated the fungal pathways to the multiforisins and compounds related to islandic acid. Heterologous expression experiments yield high titres of these compounds and pathway intermediates. The results both elucidate the pathway and offer a platform for the total biosynthesis of this class of metabolites.
UR - http://www.scopus.com/inward/record.url?scp=85175562497&partnerID=8YFLogxK
U2 - 10.1039/d3cc04758j
DO - 10.1039/d3cc04758j
M3 - Article
C2 - 37886844
AN - SCOPUS:85175562497
VL - 59
SP - 13587
EP - 13590
JO - Chemical communications
JF - Chemical communications
SN - 1359-7345
IS - 91
ER -