Details
| Original language | English |
|---|---|
| Title of host publication | Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI |
| Publisher | SPIE |
| ISBN (print) | 9780819498588 |
| Publication status | Published - 3 Mar 2014 |
| Event | Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI - San Francisco, CA, United States Duration: 1 Feb 2014 → 2 Feb 2014 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 8945 |
| ISSN (Print) | 1605-7422 |
Abstract
Tissue phantoms with defined, reliable and reproducible characteristics are crucial for the evaluation of biomedical imaging systems. For multimodal approaches, various demands on tissue phantoms have to be met in order to satisfy the needs of all modalities. We present and discuss a hydrogel phantom that was created for combined Raman spectroscopic and optoacoustic measurements imposing optical as well as acoustic requirements on the phantom. In this phantom, defined concentrations of carotenes should be available in an optically scattering and absorbing matrix to test and validate the capability of this combination of methods to quantify specific biomolecules in tissue. The main requirements on this phantom were tissue-like acoustic properties, scalable optical attenuation and incorporation of Raman active target molecules. We used a poly(vinyl alcohol) (PVA) hydrogel as the basic phantom material because of its suitable acoustic and optical characteristics but found that the incorporation of non-polar dyes like carotenoids in the hydrogel is difficult and the optical properties of the biomolecule are significantly altered by the hydrogel molecular environment and production procedure. We show and discuss challenges and solutions in the design process of a suitable tissue phantom.
Keywords
- Carotenoids, Optoacoustics, Poly(vinyl alcohol) hydrogel, Raman spectroscopy
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Materials Science(all)
- Biomaterials
- Medicine(all)
- Radiology Nuclear Medicine and imaging
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI. SPIE, 2014. 89450B (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8945).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Tissue phantoms for multimodal approaches
T2 - Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI
AU - Meinhardt-Wollweber, Merve
AU - Suhr, Christian
AU - Kniggendorf, Ann Kathrin
AU - Roth, Bernhard
PY - 2014/3/3
Y1 - 2014/3/3
N2 - Tissue phantoms with defined, reliable and reproducible characteristics are crucial for the evaluation of biomedical imaging systems. For multimodal approaches, various demands on tissue phantoms have to be met in order to satisfy the needs of all modalities. We present and discuss a hydrogel phantom that was created for combined Raman spectroscopic and optoacoustic measurements imposing optical as well as acoustic requirements on the phantom. In this phantom, defined concentrations of carotenes should be available in an optically scattering and absorbing matrix to test and validate the capability of this combination of methods to quantify specific biomolecules in tissue. The main requirements on this phantom were tissue-like acoustic properties, scalable optical attenuation and incorporation of Raman active target molecules. We used a poly(vinyl alcohol) (PVA) hydrogel as the basic phantom material because of its suitable acoustic and optical characteristics but found that the incorporation of non-polar dyes like carotenoids in the hydrogel is difficult and the optical properties of the biomolecule are significantly altered by the hydrogel molecular environment and production procedure. We show and discuss challenges and solutions in the design process of a suitable tissue phantom.
AB - Tissue phantoms with defined, reliable and reproducible characteristics are crucial for the evaluation of biomedical imaging systems. For multimodal approaches, various demands on tissue phantoms have to be met in order to satisfy the needs of all modalities. We present and discuss a hydrogel phantom that was created for combined Raman spectroscopic and optoacoustic measurements imposing optical as well as acoustic requirements on the phantom. In this phantom, defined concentrations of carotenes should be available in an optically scattering and absorbing matrix to test and validate the capability of this combination of methods to quantify specific biomolecules in tissue. The main requirements on this phantom were tissue-like acoustic properties, scalable optical attenuation and incorporation of Raman active target molecules. We used a poly(vinyl alcohol) (PVA) hydrogel as the basic phantom material because of its suitable acoustic and optical characteristics but found that the incorporation of non-polar dyes like carotenoids in the hydrogel is difficult and the optical properties of the biomolecule are significantly altered by the hydrogel molecular environment and production procedure. We show and discuss challenges and solutions in the design process of a suitable tissue phantom.
KW - Carotenoids
KW - Optoacoustics
KW - Poly(vinyl alcohol) hydrogel
KW - Raman spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=84897462285&partnerID=8YFLogxK
U2 - 10.1117/12.2038354
DO - 10.1117/12.2038354
M3 - Conference contribution
AN - SCOPUS:84897462285
SN - 9780819498588
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI
PB - SPIE
Y2 - 1 February 2014 through 2 February 2014
ER -