Details
| Original language | English |
|---|---|
| Pages (from-to) | 563-594 |
| Number of pages | 32 |
| Journal | Natural product reports |
| Volume | 31 |
| Issue number | 4 |
| Publication status | Published - Apr 2014 |
Abstract
The vinylogous Mukaiyama aldol reaction (VMAR) allows efficient access to larger segments for complex natural product synthesis, primarily polyketides, through the construction of vicinal hydroxyl and methyl groups as well as di and tri-substituted double bonds in one single operation. In this review, we will highlight stereoselective protocols that have been used in natural product synthesis and cluster them into the four groups that can be obtained from different silyl ketene acetals or enol ethers. At the beginning, an overview on different stereoselective VMARs is presented; disregarding their applications in total syntheses. This journal is
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural product reports, Vol. 31, No. 4, 04.2014, p. 563-594.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - The vinylogous Mukaiyama aldol reaction (VMAR) in natural product synthesis
AU - Kalesse, Markus
AU - Cordes, Martin
AU - Symkenberg, Gerrit
AU - Lu, Hai Hua
PY - 2014/4
Y1 - 2014/4
N2 - The vinylogous Mukaiyama aldol reaction (VMAR) allows efficient access to larger segments for complex natural product synthesis, primarily polyketides, through the construction of vicinal hydroxyl and methyl groups as well as di and tri-substituted double bonds in one single operation. In this review, we will highlight stereoselective protocols that have been used in natural product synthesis and cluster them into the four groups that can be obtained from different silyl ketene acetals or enol ethers. At the beginning, an overview on different stereoselective VMARs is presented; disregarding their applications in total syntheses. This journal is
AB - The vinylogous Mukaiyama aldol reaction (VMAR) allows efficient access to larger segments for complex natural product synthesis, primarily polyketides, through the construction of vicinal hydroxyl and methyl groups as well as di and tri-substituted double bonds in one single operation. In this review, we will highlight stereoselective protocols that have been used in natural product synthesis and cluster them into the four groups that can be obtained from different silyl ketene acetals or enol ethers. At the beginning, an overview on different stereoselective VMARs is presented; disregarding their applications in total syntheses. This journal is
UR - http://www.scopus.com/inward/record.url?scp=84896135761&partnerID=8YFLogxK
U2 - 10.1039/c3np70102f
DO - 10.1039/c3np70102f
M3 - Review article
C2 - 24595879
AN - SCOPUS:84896135761
VL - 31
SP - 563
EP - 594
JO - Natural product reports
JF - Natural product reports
SN - 0265-0568
IS - 4
ER -