Details
| Original language | English |
|---|---|
| Title of host publication | Modern Methods in Stereoselective Aldol Reactions |
| Publisher | Wiley-VCH Verlag |
| Pages | 83-154 |
| Number of pages | 72 |
| ISBN (print) | 9783527332052 |
| Publication status | Published - 6 Feb 2013 |
Abstract
The aldol reaction is one of the most predominantly used reactions for the formation of C-C bonds in synthetic organic chemistry. The vinylogous extension of this fundamental C-C bond-forming reaction, the VMAR, is unique in its atomic economy in the generation of hydroxycarbonyl compounds. The generation of the same hydroxycarbonyl compounds via other routes is sometimes cumbersome and often requires multi-step synthetic sequences. Therefore, the VMAR can be a powerful alternative to other strategies in the rational design of polyketide fragments of complex natural products. In this chapter, recent advances in the VMAR and its applications to natural product synthesis are discussed.
Keywords
- Asymmetric, Butenolides, D4 donors, Diastereoselective, Enantioselective, Natural product synthesis, Polyketides, Vinylogous Mukaiyama aldol reaction, Vinylogy
ASJC Scopus subject areas
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Modern Methods in Stereoselective Aldol Reactions. Wiley-VCH Verlag, 2013. p. 83-154.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - The Vinylogous Mukaiyama Aldol Reaction in Natural Product Synthesis
AU - Cordes, Martin
AU - Kalesse, Markus
PY - 2013/2/6
Y1 - 2013/2/6
N2 - The aldol reaction is one of the most predominantly used reactions for the formation of C-C bonds in synthetic organic chemistry. The vinylogous extension of this fundamental C-C bond-forming reaction, the VMAR, is unique in its atomic economy in the generation of hydroxycarbonyl compounds. The generation of the same hydroxycarbonyl compounds via other routes is sometimes cumbersome and often requires multi-step synthetic sequences. Therefore, the VMAR can be a powerful alternative to other strategies in the rational design of polyketide fragments of complex natural products. In this chapter, recent advances in the VMAR and its applications to natural product synthesis are discussed.
AB - The aldol reaction is one of the most predominantly used reactions for the formation of C-C bonds in synthetic organic chemistry. The vinylogous extension of this fundamental C-C bond-forming reaction, the VMAR, is unique in its atomic economy in the generation of hydroxycarbonyl compounds. The generation of the same hydroxycarbonyl compounds via other routes is sometimes cumbersome and often requires multi-step synthetic sequences. Therefore, the VMAR can be a powerful alternative to other strategies in the rational design of polyketide fragments of complex natural products. In this chapter, recent advances in the VMAR and its applications to natural product synthesis are discussed.
KW - Asymmetric
KW - Butenolides
KW - D4 donors
KW - Diastereoselective
KW - Enantioselective
KW - Natural product synthesis
KW - Polyketides
KW - Vinylogous Mukaiyama aldol reaction
KW - Vinylogy
UR - http://www.scopus.com/inward/record.url?scp=84885719656&partnerID=8YFLogxK
U2 - 10.1002/9783527656714.ch2
DO - 10.1002/9783527656714.ch2
M3 - Contribution to book/anthology
AN - SCOPUS:84885719656
SN - 9783527332052
SP - 83
EP - 154
BT - Modern Methods in Stereoselective Aldol Reactions
PB - Wiley-VCH Verlag
ER -