Details
| Original language | English |
|---|---|
| Pages (from-to) | 11381-11384 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 45 |
| Publication status | Published - 5 Nov 2012 |
Abstract
Leading the way: The synthesis of natural products with new biological targets is one of the driving forces for the development of new antibiotics. The synthesis of the two secondary metabolites corallopyronin and myxopyronin (see picture) have been achieved, which are prominent leads for the inhibition of bacterial RNA polymerase.
Keywords
- corallopyronin, myxobacteria, protecting groups, RNA polymerase, Walsh coupling
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
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In: Angewandte Chemie - International Edition, Vol. 51, No. 45, 05.11.2012, p. 11381-11384.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The total synthesis of corallopyronin A and myxopyronin B
AU - Rentsch, Andreas
AU - Kalesse, Markus
PY - 2012/11/5
Y1 - 2012/11/5
N2 - Leading the way: The synthesis of natural products with new biological targets is one of the driving forces for the development of new antibiotics. The synthesis of the two secondary metabolites corallopyronin and myxopyronin (see picture) have been achieved, which are prominent leads for the inhibition of bacterial RNA polymerase.
AB - Leading the way: The synthesis of natural products with new biological targets is one of the driving forces for the development of new antibiotics. The synthesis of the two secondary metabolites corallopyronin and myxopyronin (see picture) have been achieved, which are prominent leads for the inhibition of bacterial RNA polymerase.
KW - corallopyronin
KW - myxobacteria
KW - protecting groups
KW - RNA polymerase
KW - Walsh coupling
UR - http://www.scopus.com/inward/record.url?scp=84868087263&partnerID=8YFLogxK
U2 - 10.1002/anie.201206560
DO - 10.1002/anie.201206560
M3 - Article
C2 - 23042599
AN - SCOPUS:84868087263
VL - 51
SP - 11381
EP - 11384
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 45
ER -