Details
| Original language | English |
|---|---|
| Article number | 2241 |
| Journal | International Journal of Environmental Research and Public Health |
| Volume | 15 |
| Issue number | 10 |
| Publication status | Published - 12 Oct 2018 |
Abstract
Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.
Keywords
- 25-hydroxyvitamin D, Autism, Brain, Breast milk, DBP, Gestational diabetes, Pre-eclampsia, Vitamin D, Vitamin D binding protein
ASJC Scopus subject areas
- Environmental Science(all)
- Pollution
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Environmental Science(all)
- Health, Toxicology and Mutagenesis
Sustainable Development Goals
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In: International Journal of Environmental Research and Public Health, Vol. 15, No. 10, 2241, 12.10.2018.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data
AU - Pilz, Stefan
AU - Zittermann, Armin
AU - Obeid, Rima
AU - Hahn, Andreas
AU - Pludowski, Pawel
AU - Trummer, Christian
AU - Lerchbaum, Elisabeth
AU - Pérez-López, Faustino R.
AU - Karras, Spyridon N.
AU - März, Winfried
PY - 2018/10/12
Y1 - 2018/10/12
N2 - Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.
AB - Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.
KW - 25-hydroxyvitamin D
KW - Autism
KW - Brain
KW - Breast milk
KW - DBP
KW - Gestational diabetes
KW - Pre-eclampsia
KW - Vitamin D
KW - Vitamin D binding protein
UR - http://www.scopus.com/inward/record.url?scp=85055079841&partnerID=8YFLogxK
U2 - 10.3390/ijerph15102241
DO - 10.3390/ijerph15102241
M3 - Review article
C2 - 30322097
AN - SCOPUS:85055079841
VL - 15
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 10
M1 - 2241
ER -