The rise of continuous flow biocatalysis-fundamentals, very recent developments and future perspectives

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Original languageEnglish
Pages (from-to)2155-2184
Number of pages30
JournalReaction Chemistry and Engineering
Volume5
Issue number12
Early online date15 Oct 2020
Publication statusPublished - Dec 2020
Externally publishedYes

Abstract

Biocatalysis community has witnessed a drastic increase in the number of studies for the use of enzymes in continuously operated flow reactors. This significant interest arose from the possibility of combining the strengths of the two worlds: enhanced mass transfer and resource efficient synthesis achieved in flow chemistry at micro-scales and excellent selectivities obtained in biocatalysis. Within this review, we present very recent (from 2018 to September 2020) developments in the field of biocatalysis in continuously operated systems. Briefly, we describe the fundamentals of continuously operated reactors with a special focus on enzyme-catalyzed reactions. We devoted special attention on future perspectives in this key emerging technological area ranging from process analytical technologies to digitalization. This journal is

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The rise of continuous flow biocatalysis-fundamentals, very recent developments and future perspectives. / De Santis, Piera; Meyer, Lars-Erik; Kara, Selin.
In: Reaction Chemistry and Engineering, Vol. 5, No. 12, 12.2020, p. 2155-2184.

Research output: Contribution to journalArticleResearchpeer review

De Santis P, Meyer LE, Kara S. The rise of continuous flow biocatalysis-fundamentals, very recent developments and future perspectives. Reaction Chemistry and Engineering. 2020 Dec;5(12):2155-2184. Epub 2020 Oct 15. doi: 10.1039/d0re00335b
De Santis, Piera ; Meyer, Lars-Erik ; Kara, Selin. / The rise of continuous flow biocatalysis-fundamentals, very recent developments and future perspectives. In: Reaction Chemistry and Engineering. 2020 ; Vol. 5, No. 12. pp. 2155-2184.
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