Details
| Original language | English |
|---|---|
| Article number | 1801178 |
| Journal | Molecular Nutrition and Food Research |
| Volume | 63 |
| Issue number | 6 |
| Early online date | 28 Jan 2019 |
| Publication status | Published - 21 Mar 2019 |
Abstract
Scope: The nutrition societies of Germany, Austria, and Switzerland are the joint editors of the “D-A-CH reference values for nutrient intake”, which are revised regularly. Methods and Results: By reviewing vitamin-B 12 -related biomarker studies, the reference values for vitamin B 12 were revised in 2018. For adults, the estimated intake is based on the adequate serum concentrations of holotranscobalamin and methylmalonic acid. The estimated values for children and adolescents are extrapolated from the adult reference value by considering differences in body mass, an allometric exponent, and growth factors. For infants below 4 months of age, an estimated value is set based on the vitamin B 12 intake via breast milk. The reference values for pregnant and lactating women consider the requirements for the fetus and for loss via breast milk. The estimated values for vitamin B 12 intake for infants, children, and adolescents range from 0.5 to 4.0 µg d −1 . For adults, the estimated values are set at 4.0 µg d −1 , and for pregnant and lactating women, they are set at 4.5 and 5.5 µg d −1 , respectively. Conclusion: Based on the data of several vitamin B 12 status biomarkers studies, the reference value for vitamin B 12 intake for adults is raised from 3.0 to 4.0 µg d −1 .
Keywords
- cobalamine, holo-transcobalamin, methylmalonic acid, reference value, vitamin B
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Agricultural and Biological Sciences(all)
- Food Science
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In: Molecular Nutrition and Food Research, Vol. 63, No. 6, 1801178, 21.03.2019.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The Revised D-A-CH-Reference Values for the Intake of Vitamin B12 : Prevention of Deficiency and Beyond
AU - Ströhle, A.
AU - Richter, Margit
AU - González-Gross, M.
AU - Neuhäuser-Berthold, Monika
AU - Wagner, K.H.
AU - Leschik-Bonnet, E.
AU - Egert, S.
N1 - Funding information: A.S. conducted the literature research and drafted the manuscript. M.R. organized and coordinated the revision of the D-A-CH reference values. M.R., M.G.G., M.N.-B., K.-H. W., E. L.-B., and S.E. contributed to the conception of the manuscript and interpreted the data. All authors read and approved the final manuscript. The authors are indebted to Christine Brombach, Sabine Ellinger, Helmut Heseker, Stefan Lorkowski, Birte Peterson-Sperlich, Jürgen Stolz, Daniela Strohm, and Bernard Watzl for their valuable contributions to the preparation of the revised reference values for vitamin B12 intake. The authors were named for the German Nutrition Society (DGE) after initial online publication on January 28, 2019.
PY - 2019/3/21
Y1 - 2019/3/21
N2 - Scope: The nutrition societies of Germany, Austria, and Switzerland are the joint editors of the “D-A-CH reference values for nutrient intake”, which are revised regularly. Methods and Results: By reviewing vitamin-B 12 -related biomarker studies, the reference values for vitamin B 12 were revised in 2018. For adults, the estimated intake is based on the adequate serum concentrations of holotranscobalamin and methylmalonic acid. The estimated values for children and adolescents are extrapolated from the adult reference value by considering differences in body mass, an allometric exponent, and growth factors. For infants below 4 months of age, an estimated value is set based on the vitamin B 12 intake via breast milk. The reference values for pregnant and lactating women consider the requirements for the fetus and for loss via breast milk. The estimated values for vitamin B 12 intake for infants, children, and adolescents range from 0.5 to 4.0 µg d −1 . For adults, the estimated values are set at 4.0 µg d −1 , and for pregnant and lactating women, they are set at 4.5 and 5.5 µg d −1 , respectively. Conclusion: Based on the data of several vitamin B 12 status biomarkers studies, the reference value for vitamin B 12 intake for adults is raised from 3.0 to 4.0 µg d −1 .
AB - Scope: The nutrition societies of Germany, Austria, and Switzerland are the joint editors of the “D-A-CH reference values for nutrient intake”, which are revised regularly. Methods and Results: By reviewing vitamin-B 12 -related biomarker studies, the reference values for vitamin B 12 were revised in 2018. For adults, the estimated intake is based on the adequate serum concentrations of holotranscobalamin and methylmalonic acid. The estimated values for children and adolescents are extrapolated from the adult reference value by considering differences in body mass, an allometric exponent, and growth factors. For infants below 4 months of age, an estimated value is set based on the vitamin B 12 intake via breast milk. The reference values for pregnant and lactating women consider the requirements for the fetus and for loss via breast milk. The estimated values for vitamin B 12 intake for infants, children, and adolescents range from 0.5 to 4.0 µg d −1 . For adults, the estimated values are set at 4.0 µg d −1 , and for pregnant and lactating women, they are set at 4.5 and 5.5 µg d −1 , respectively. Conclusion: Based on the data of several vitamin B 12 status biomarkers studies, the reference value for vitamin B 12 intake for adults is raised from 3.0 to 4.0 µg d −1 .
KW - cobalamine
KW - holo-transcobalamin
KW - methylmalonic acid
KW - reference value
KW - vitamin B
UR - http://www.scopus.com/inward/record.url?scp=85060712065&partnerID=8YFLogxK
U2 - 10.1002/mnfr.201801178
DO - 10.1002/mnfr.201801178
M3 - Article
VL - 63
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
SN - 1613-4125
IS - 6
M1 - 1801178
ER -