Details
| Original language | English |
|---|---|
| Pages (from-to) | 4445-4450 |
| Number of pages | 6 |
| Journal | Chemistry - A European Journal |
| Volume | 6 |
| Issue number | 24 |
| Publication status | Published - 27 Nov 2000 |
Abstract
A polymer-assisted organic synthesis that combines the concept of solid-phase synthesis with the idea of polymer-supported scavenging reagents has recently appeared on the chemistry scene. This technique has frequently been termed the "resin-capture-release" methodology and is initiated by the immobilization of a small molecule on a polymeric support. This intermediate is subjected to a second transformation by adding a new reaction partner in solution. This reactant plays two roles: a) the chemical alteration of the polymer-bound intermediate and b) the simultaneous release of this reaction product from the resin back into solution. This new concept is presented and future prospects are discussed.
Keywords
- Combinatorial chemistry, Functionalized polymers, Reagents, Solid-phase synthesis
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Organic Chemistry
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Chemistry - A European Journal, Vol. 6, No. 24, 27.11.2000, p. 4445-4450.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The "resin-capture-release" hybrid technique
T2 - A merger between solid- and solution-phase synthesis
AU - Kirschning, Andreas
AU - Monenschein, Holger
AU - Wittenberg, Rüdiger
PY - 2000/11/27
Y1 - 2000/11/27
N2 - A polymer-assisted organic synthesis that combines the concept of solid-phase synthesis with the idea of polymer-supported scavenging reagents has recently appeared on the chemistry scene. This technique has frequently been termed the "resin-capture-release" methodology and is initiated by the immobilization of a small molecule on a polymeric support. This intermediate is subjected to a second transformation by adding a new reaction partner in solution. This reactant plays two roles: a) the chemical alteration of the polymer-bound intermediate and b) the simultaneous release of this reaction product from the resin back into solution. This new concept is presented and future prospects are discussed.
AB - A polymer-assisted organic synthesis that combines the concept of solid-phase synthesis with the idea of polymer-supported scavenging reagents has recently appeared on the chemistry scene. This technique has frequently been termed the "resin-capture-release" methodology and is initiated by the immobilization of a small molecule on a polymeric support. This intermediate is subjected to a second transformation by adding a new reaction partner in solution. This reactant plays two roles: a) the chemical alteration of the polymer-bound intermediate and b) the simultaneous release of this reaction product from the resin back into solution. This new concept is presented and future prospects are discussed.
KW - Combinatorial chemistry
KW - Functionalized polymers
KW - Reagents
KW - Solid-phase synthesis
UR - http://www.scopus.com/inward/record.url?scp=0034671385&partnerID=8YFLogxK
U2 - 10.1002/1521-3765(20001215)6:24<4445::AID-CHEM4445>3.0.CO;2-W
DO - 10.1002/1521-3765(20001215)6:24<4445::AID-CHEM4445>3.0.CO;2-W
M3 - Article
C2 - 11192076
AN - SCOPUS:0034671385
VL - 6
SP - 4445
EP - 4450
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
SN - 0947-6539
IS - 24
ER -