Details
| Original language | English |
|---|---|
| Pages (from-to) | 256-259 |
| Number of pages | 4 |
| Journal | Current Genetics |
| Volume | 24 |
| Issue number | 3 |
| Publication status | Published - Sept 1993 |
| Externally published | Yes |
Abstract
The structural organization of a nuclear gene encoding cytochrome c1 from potato was determined. The gene spans 5.1 kb and contains eight introns. All intron/exon junctions follow the GT/AG rule. Functional domains of the mature cytochrome c1 protein are located on separate exons. The presequence, which targets the cytochrome c1 precursor to the mitochondrion and to the correct intra-mitochondrial location, is encoded on the first four exons. The largest intron (2.8 kb) separates the information for mitochondrial targeting from the "intra-mitochondrial sorting domain" of the cytochrome c1 protein. In contrast to other organellar precursor proteins, there is no intron between the DNA sequence encoding the presequence and the mature protein. This may indicate that during evolution the genetic information for the prokaryotic cytochrome c1 was transferred to the nucleus together with the bacterial secretion signal which is structurally and functionally related to "intramitochondrial sorting domains".
Keywords
- Cytochrome c reductase, Cytochrome c, Mitochondria, Presequence
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Genetics
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Current Genetics, Vol. 24, No. 3, 09.1993, p. 256-259.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The presequence of cytochrome c1 from potato mitochondria is encoded on four exons
AU - Wegener, Sigrum
AU - Schmitz, Udo
PY - 1993/9
Y1 - 1993/9
N2 - The structural organization of a nuclear gene encoding cytochrome c1 from potato was determined. The gene spans 5.1 kb and contains eight introns. All intron/exon junctions follow the GT/AG rule. Functional domains of the mature cytochrome c1 protein are located on separate exons. The presequence, which targets the cytochrome c1 precursor to the mitochondrion and to the correct intra-mitochondrial location, is encoded on the first four exons. The largest intron (2.8 kb) separates the information for mitochondrial targeting from the "intra-mitochondrial sorting domain" of the cytochrome c1 protein. In contrast to other organellar precursor proteins, there is no intron between the DNA sequence encoding the presequence and the mature protein. This may indicate that during evolution the genetic information for the prokaryotic cytochrome c1 was transferred to the nucleus together with the bacterial secretion signal which is structurally and functionally related to "intramitochondrial sorting domains".
AB - The structural organization of a nuclear gene encoding cytochrome c1 from potato was determined. The gene spans 5.1 kb and contains eight introns. All intron/exon junctions follow the GT/AG rule. Functional domains of the mature cytochrome c1 protein are located on separate exons. The presequence, which targets the cytochrome c1 precursor to the mitochondrion and to the correct intra-mitochondrial location, is encoded on the first four exons. The largest intron (2.8 kb) separates the information for mitochondrial targeting from the "intra-mitochondrial sorting domain" of the cytochrome c1 protein. In contrast to other organellar precursor proteins, there is no intron between the DNA sequence encoding the presequence and the mature protein. This may indicate that during evolution the genetic information for the prokaryotic cytochrome c1 was transferred to the nucleus together with the bacterial secretion signal which is structurally and functionally related to "intramitochondrial sorting domains".
KW - Cytochrome c reductase
KW - Cytochrome c
KW - Mitochondria
KW - Presequence
UR - http://www.scopus.com/inward/record.url?scp=0027340233&partnerID=8YFLogxK
U2 - 10.1007/BF00351800
DO - 10.1007/BF00351800
M3 - Article
C2 - 8221935
AN - SCOPUS:0027340233
VL - 24
SP - 256
EP - 259
JO - Current Genetics
JF - Current Genetics
SN - 0172-8083
IS - 3
ER -