Details
| Original language | English |
|---|---|
| Pages (from-to) | 1043-1045 |
| Number of pages | 3 |
| Journal | International Journal of Biochemistry and Cell Biology |
| Volume | 29 |
| Issue number | 8-9 |
| Publication status | Published - 1997 |
Abstract
The mitochondrial processing peptidase (MPP) is a heterodimeric enzyme which plays an essential role in mitochondrial protein import. It cleaves off the N-terminal targeting signals of nuclear encoded mitochondrial proteins upon their transport into the organelle. In mammals and yeast the enzyme is localized in the mitochondrial matrix while in plants it is integrated into a protein complex of the respiratory chain. As the activity of MPP is essential for the viability of eukaryotic cells it is conceivable that inhibitors of MPP which are specific for the soluble enzyme only present in fungi and animals may work as fungicides or insecticides.
Keywords
- Bc omplex, Mitochondria, Protein import, Protein processing
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
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In: International Journal of Biochemistry and Cell Biology, Vol. 29, No. 8-9, 1997, p. 1043-1045.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The mitochondrial processing peptidase
AU - Braun, Hans-Peter
AU - Schmitz, Udo
N1 - Funding information: Acknowledgement-This work is supported by.the Deutsche Forschungsgemeinschaft.
PY - 1997
Y1 - 1997
N2 - The mitochondrial processing peptidase (MPP) is a heterodimeric enzyme which plays an essential role in mitochondrial protein import. It cleaves off the N-terminal targeting signals of nuclear encoded mitochondrial proteins upon their transport into the organelle. In mammals and yeast the enzyme is localized in the mitochondrial matrix while in plants it is integrated into a protein complex of the respiratory chain. As the activity of MPP is essential for the viability of eukaryotic cells it is conceivable that inhibitors of MPP which are specific for the soluble enzyme only present in fungi and animals may work as fungicides or insecticides.
AB - The mitochondrial processing peptidase (MPP) is a heterodimeric enzyme which plays an essential role in mitochondrial protein import. It cleaves off the N-terminal targeting signals of nuclear encoded mitochondrial proteins upon their transport into the organelle. In mammals and yeast the enzyme is localized in the mitochondrial matrix while in plants it is integrated into a protein complex of the respiratory chain. As the activity of MPP is essential for the viability of eukaryotic cells it is conceivable that inhibitors of MPP which are specific for the soluble enzyme only present in fungi and animals may work as fungicides or insecticides.
KW - Bc omplex
KW - Mitochondria
KW - Protein import
KW - Protein processing
UR - http://www.scopus.com/inward/record.url?scp=0030728696&partnerID=8YFLogxK
U2 - 10.1016/S1357-2725(97)00032-0
DO - 10.1016/S1357-2725(97)00032-0
M3 - Article
C2 - 9415998
AN - SCOPUS:0030728696
VL - 29
SP - 1043
EP - 1045
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
SN - 1357-2725
IS - 8-9
ER -