Details
| Original language | English |
|---|---|
| Pages (from-to) | 752-757 |
| Number of pages | 6 |
| Journal | Angewandte Chemie |
| Volume | 51 |
| Issue number | 3 |
| Publication status | Published - 1 Dec 2011 |
Abstract
Working hand in hand! The synthetic power of three mutant strains that produce ansamitocin and geldanamycin is combined with chemical synthesis, thus leading to 27 new ansamitocin derivatives. Structure-activity studies show that the N of the carbinolamide moiety is not important for cytotoxic activity but the α orientation of the OH group at C9 is key [see structures; chemical synthesis (red), mutasynthesis (blue), biosynthesis (black)].
Keywords
- antitumor agents, mutasynthesis, natural products, polyketides, semisynthesis
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: Angewandte Chemie , Vol. 51, No. 3, 01.12.2011, p. 752-757.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The interplay between mutasynthesis and semisynthesis
T2 - Generation and evaluation of an ansamitocin library
AU - Eichner, Simone
AU - Knobloch, Tobias
AU - Floss, Heinz G.
AU - Fohrer, Jörg
AU - Harmrolfs, Kirsten
AU - Hermane, Jekaterina
AU - Schulz, Anne
AU - Sasse, Florenz
AU - Spiteller, Peter
AU - Taft, Florian
AU - Kirschning, Andreas
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Working hand in hand! The synthetic power of three mutant strains that produce ansamitocin and geldanamycin is combined with chemical synthesis, thus leading to 27 new ansamitocin derivatives. Structure-activity studies show that the N of the carbinolamide moiety is not important for cytotoxic activity but the α orientation of the OH group at C9 is key [see structures; chemical synthesis (red), mutasynthesis (blue), biosynthesis (black)].
AB - Working hand in hand! The synthetic power of three mutant strains that produce ansamitocin and geldanamycin is combined with chemical synthesis, thus leading to 27 new ansamitocin derivatives. Structure-activity studies show that the N of the carbinolamide moiety is not important for cytotoxic activity but the α orientation of the OH group at C9 is key [see structures; chemical synthesis (red), mutasynthesis (blue), biosynthesis (black)].
KW - antitumor agents
KW - mutasynthesis
KW - natural products
KW - polyketides
KW - semisynthesis
UR - http://www.scopus.com/inward/record.url?scp=84855809520&partnerID=8YFLogxK
U2 - 10.1002/anie.201106249
DO - 10.1002/anie.201106249
M3 - Article
C2 - 22135226
AN - SCOPUS:84855809520
VL - 51
SP - 752
EP - 757
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 3
ER -