Details
| Original language | English |
|---|---|
| Pages (from-to) | 29-36 |
| Number of pages | 8 |
| Journal | Israel journal of chemistry |
| Volume | 59 |
| Issue number | 1 |
| Early online date | 28 Mar 2019 |
| Publication status | Published - 29 Mar 2019 |
Abstract
In early times, the drug discovery process was mainly based on profiling of new medications in in vivo systems. In the absence of knowledge on enzymatic structures, biochemical signaling or precise cellular processes, researchers were dependent on knowledgeable readout of phenotypic effects in living animals.
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
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In: Israel journal of chemistry, Vol. 59, No. 1, 29.03.2019, p. 29-36.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - The Impact of Chemical Biology on Drug Discovery
AU - Plettenburg, Oliver
N1 - Funding information: I am grateful for financial support by the Impuls und Vernetzungsfonds of the Helmholtz Association (Rebirth4Munich). I also thank F. Neure for providing the graphical illustrations.
PY - 2019/3/29
Y1 - 2019/3/29
N2 - In early times, the drug discovery process was mainly based on profiling of new medications in in vivo systems. In the absence of knowledge on enzymatic structures, biochemical signaling or precise cellular processes, researchers were dependent on knowledgeable readout of phenotypic effects in living animals.
AB - In early times, the drug discovery process was mainly based on profiling of new medications in in vivo systems. In the absence of knowledge on enzymatic structures, biochemical signaling or precise cellular processes, researchers were dependent on knowledgeable readout of phenotypic effects in living animals.
UR - http://www.scopus.com/inward/record.url?scp=85063615855&partnerID=8YFLogxK
U2 - 10.1002/ijch.201900007
DO - 10.1002/ijch.201900007
M3 - Review article
AN - SCOPUS:85063615855
VL - 59
SP - 29
EP - 36
JO - Israel journal of chemistry
JF - Israel journal of chemistry
SN - 0021-2148
IS - 1
ER -