Details
| Original language | English |
|---|---|
| Pages (from-to) | H1239-H1243 |
| Journal | American Journal of Physiology - Heart and Circulatory Physiology |
| Volume | 323 |
| Issue number | 6 |
| Early online date | 28 Nov 2022 |
| Publication status | Published - Dec 2022 |
Abstract
The current evidence suggests that the healthy heart does not sense the optimal cardiac output because the different organ systems that influence cardiac function do not interact to adjust their individual responses towards a specific Q. Consequently, it is conceivable that the complex cycle of cardiac contraction and relaxation must occur for reasons other than to produce a specific target Q and that there is likely an as of yet undiscovered overarching principle in the cardiovascular system that explains the combined effects of the prevailing preload, afterload and contractility. Future research should embrace the possibility of a different purpose to cardiac function than previously assumed and examine the biological capacity of this fascinating organ accordingly.
Keywords
- cardiac output, exercise, heart failure, hypertension, twist
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Physiology
- Medicine(all)
- Cardiology and Cardiovascular Medicine
- Medicine(all)
- Physiology (medical)
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In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 323, No. 6, 12.2022, p. H1239-H1243.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The healthy heart does not control a specific cardiac output
T2 - a plea for a new interpretation of normal cardiac function
AU - Stöhr, Eric J
PY - 2022/12
Y1 - 2022/12
N2 - The current evidence suggests that the healthy heart does not sense the optimal cardiac output because the different organ systems that influence cardiac function do not interact to adjust their individual responses towards a specific Q. Consequently, it is conceivable that the complex cycle of cardiac contraction and relaxation must occur for reasons other than to produce a specific target Q and that there is likely an as of yet undiscovered overarching principle in the cardiovascular system that explains the combined effects of the prevailing preload, afterload and contractility. Future research should embrace the possibility of a different purpose to cardiac function than previously assumed and examine the biological capacity of this fascinating organ accordingly.
AB - The current evidence suggests that the healthy heart does not sense the optimal cardiac output because the different organ systems that influence cardiac function do not interact to adjust their individual responses towards a specific Q. Consequently, it is conceivable that the complex cycle of cardiac contraction and relaxation must occur for reasons other than to produce a specific target Q and that there is likely an as of yet undiscovered overarching principle in the cardiovascular system that explains the combined effects of the prevailing preload, afterload and contractility. Future research should embrace the possibility of a different purpose to cardiac function than previously assumed and examine the biological capacity of this fascinating organ accordingly.
KW - cardiac output
KW - exercise
KW - heart failure
KW - hypertension
KW - twist
UR - http://www.scopus.com/inward/record.url?scp=85142941025&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.00535.2022
DO - 10.1152/ajpheart.00535.2022
M3 - Article
C2 - 36269649
VL - 323
SP - H1239-H1243
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
SN - 0363-6135
IS - 6
ER -