Details
| Original language | English |
|---|---|
| Pages (from-to) | 1885-1893 |
| Number of pages | 9 |
| Journal | Journal of Organic Chemistry |
| Volume | 66 |
| Issue number | 5 |
| Publication status | Published - 9 Mar 2001 |
Abstract
The first total synthesis of ratjadone was achieved using a highly convergent approach joining three subunits together with a Wittig olefination and a selective Heck reaction as the pivotal steps. Besides establishing a robust and reliable route for the synthesis of this orphan ligand, the configuration of unknown stereocenters could also be determined. This synthesis not only provides an additional access to a biologically important compound but also enables the synthesis structural analogues for biological target identification.
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
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In: Journal of Organic Chemistry, Vol. 66, No. 5, 09.03.2001, p. 1885-1893.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The first total synthesis of (+)-ratjadone
AU - Bhatt, U.
AU - Christmann, M.
AU - Quitschalle, M.
AU - Claus, E.
AU - Kalesse, M.
PY - 2001/3/9
Y1 - 2001/3/9
N2 - The first total synthesis of ratjadone was achieved using a highly convergent approach joining three subunits together with a Wittig olefination and a selective Heck reaction as the pivotal steps. Besides establishing a robust and reliable route for the synthesis of this orphan ligand, the configuration of unknown stereocenters could also be determined. This synthesis not only provides an additional access to a biologically important compound but also enables the synthesis structural analogues for biological target identification.
AB - The first total synthesis of ratjadone was achieved using a highly convergent approach joining three subunits together with a Wittig olefination and a selective Heck reaction as the pivotal steps. Besides establishing a robust and reliable route for the synthesis of this orphan ligand, the configuration of unknown stereocenters could also be determined. This synthesis not only provides an additional access to a biologically important compound but also enables the synthesis structural analogues for biological target identification.
UR - http://www.scopus.com/inward/record.url?scp=0035831117&partnerID=8YFLogxK
U2 - 10.1021/jo005768g
DO - 10.1021/jo005768g
M3 - Article
C2 - 11262141
AN - SCOPUS:0035831117
VL - 66
SP - 1885
EP - 1893
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 5
ER -