Details
| Original language | English |
|---|---|
| Article number | 114069 |
| Journal | Advanced drug delivery reviews |
| Volume | 181 |
| Early online date | 25 Nov 2021 |
| Publication status | Published - Feb 2022 |
Abstract
Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their function is controlled by their direct microenvironment, the HSC niche in the bone marrow. Although the importance of the extracellular matrix (ECM) in the niche by orchestrating niche architecture and cellular function is widely acknowledged, it is still underexplored. In this review, we provide a comprehensive overview of the ECM in HSC niches. For this purpose, we first briefly outline HSC niche biology and then review the role of the different classes of ECM molecules in the niche one by one and how they are perceived by cells. Matrix remodeling and the emerging importance of biophysics in HSC niche function are discussed. Finally, the application of the current knowledge of ECM in the niche in form of artificial HSC niches for HSC expansion or targeted differentiation as well as drug testing is reviewed.
Keywords
- Bone marrow, Extracellular matrix, Hematopoietic stem cell niche
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
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In: Advanced drug delivery reviews, Vol. 181, 114069, 02.2022.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The extracellular matrix of hematopoietic stem cell niches
AU - Lee-Thedieck, Cornelia
AU - Schertl, Peter
AU - Klein, Gerd
N1 - Funding Information: This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 757490). This work has been carried out within the framework of the SMART BIOTECS alliance between the Technische Universität Braunschweig and the Leibniz Universität Hannover. This initiative is supported by the Ministry of Science and Culture (MWK) of Lower Saxony, Germany.
PY - 2022/2
Y1 - 2022/2
N2 - Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their function is controlled by their direct microenvironment, the HSC niche in the bone marrow. Although the importance of the extracellular matrix (ECM) in the niche by orchestrating niche architecture and cellular function is widely acknowledged, it is still underexplored. In this review, we provide a comprehensive overview of the ECM in HSC niches. For this purpose, we first briefly outline HSC niche biology and then review the role of the different classes of ECM molecules in the niche one by one and how they are perceived by cells. Matrix remodeling and the emerging importance of biophysics in HSC niche function are discussed. Finally, the application of the current knowledge of ECM in the niche in form of artificial HSC niches for HSC expansion or targeted differentiation as well as drug testing is reviewed.
AB - Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their function is controlled by their direct microenvironment, the HSC niche in the bone marrow. Although the importance of the extracellular matrix (ECM) in the niche by orchestrating niche architecture and cellular function is widely acknowledged, it is still underexplored. In this review, we provide a comprehensive overview of the ECM in HSC niches. For this purpose, we first briefly outline HSC niche biology and then review the role of the different classes of ECM molecules in the niche one by one and how they are perceived by cells. Matrix remodeling and the emerging importance of biophysics in HSC niche function are discussed. Finally, the application of the current knowledge of ECM in the niche in form of artificial HSC niches for HSC expansion or targeted differentiation as well as drug testing is reviewed.
KW - Bone marrow
KW - Extracellular matrix
KW - Hematopoietic stem cell niche
UR - http://www.scopus.com/inward/record.url?scp=85122640210&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2021.114069
DO - 10.1016/j.addr.2021.114069
M3 - Article
VL - 181
JO - Advanced drug delivery reviews
JF - Advanced drug delivery reviews
SN - 0169-409X
M1 - 114069
ER -