Details
| Original language | English |
|---|---|
| Pages (from-to) | 227-243 |
| Number of pages | 17 |
| Journal | Journal of Adhesion Science and Technology |
| Volume | 27 |
| Issue number | 3 |
| Publication status | Published - 30 May 2013 |
| Externally published | Yes |
Abstract
Microneedles are small-scale devices that may be used for drug delivery and biosensing. In this study, the forces required for mechanical failure, the modes of mechanical failure, as well as the mechanisms for microneedle penetration into porcine skin were examined. Microneedles produced from the acrylate-based polymer e-Shell 200 using an indirect rapid prototyping approach involving two-photon polymerization and poly(dimethylsiloxane) micromolding were found to possess sufficient strength for penetration of porcine skin. The failure forces were an order of magnitude greater than the forces necessary for full insertion into the skin. Bending was the most common form of failure; an increasing aspect ratio and a decreasing tip diameter were associated with lower failure forces. Video captured during skin penetration revealed that microneedle penetration into the skin occurred by means of a series of insertions and not by means of a single insertion event. Images obtained during and after skin penetration confirmed microneedle penetration of skin as well as transdermal delivery of lucifer yellow dye. These findings shed insight into the mechanisms of microneedle penetration and failure, facilitating design improvements for polymer microneedles.
Keywords
- acrylate-based polymer, micromolding, microneedle, porcine skin
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Engineering(all)
- Mechanics of Materials
- Physics and Astronomy(all)
- Surfaces and Interfaces
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Materials Chemistry
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In: Journal of Adhesion Science and Technology, Vol. 27, No. 3, 30.05.2013, p. 227-243.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The effects of geometry on skin penetration and failure of polymer microneedles
AU - Gittard, Shaun D.
AU - Chen, Bo
AU - Xu, Huadong
AU - Ovsianikov, Aleksandr
AU - Chichkov, Boris N.
AU - Monteiro-Riviere, Nancy A.
AU - Narayan, Roger J.
PY - 2013/5/30
Y1 - 2013/5/30
N2 - Microneedles are small-scale devices that may be used for drug delivery and biosensing. In this study, the forces required for mechanical failure, the modes of mechanical failure, as well as the mechanisms for microneedle penetration into porcine skin were examined. Microneedles produced from the acrylate-based polymer e-Shell 200 using an indirect rapid prototyping approach involving two-photon polymerization and poly(dimethylsiloxane) micromolding were found to possess sufficient strength for penetration of porcine skin. The failure forces were an order of magnitude greater than the forces necessary for full insertion into the skin. Bending was the most common form of failure; an increasing aspect ratio and a decreasing tip diameter were associated with lower failure forces. Video captured during skin penetration revealed that microneedle penetration into the skin occurred by means of a series of insertions and not by means of a single insertion event. Images obtained during and after skin penetration confirmed microneedle penetration of skin as well as transdermal delivery of lucifer yellow dye. These findings shed insight into the mechanisms of microneedle penetration and failure, facilitating design improvements for polymer microneedles.
AB - Microneedles are small-scale devices that may be used for drug delivery and biosensing. In this study, the forces required for mechanical failure, the modes of mechanical failure, as well as the mechanisms for microneedle penetration into porcine skin were examined. Microneedles produced from the acrylate-based polymer e-Shell 200 using an indirect rapid prototyping approach involving two-photon polymerization and poly(dimethylsiloxane) micromolding were found to possess sufficient strength for penetration of porcine skin. The failure forces were an order of magnitude greater than the forces necessary for full insertion into the skin. Bending was the most common form of failure; an increasing aspect ratio and a decreasing tip diameter were associated with lower failure forces. Video captured during skin penetration revealed that microneedle penetration into the skin occurred by means of a series of insertions and not by means of a single insertion event. Images obtained during and after skin penetration confirmed microneedle penetration of skin as well as transdermal delivery of lucifer yellow dye. These findings shed insight into the mechanisms of microneedle penetration and failure, facilitating design improvements for polymer microneedles.
KW - acrylate-based polymer
KW - micromolding
KW - microneedle
KW - porcine skin
UR - http://www.scopus.com/inward/record.url?scp=84874631649&partnerID=8YFLogxK
U2 - 10.1080/01694243.2012.705101
DO - 10.1080/01694243.2012.705101
M3 - Article
AN - SCOPUS:84874631649
VL - 27
SP - 227
EP - 243
JO - Journal of Adhesion Science and Technology
JF - Journal of Adhesion Science and Technology
SN - 0169-4243
IS - 3
ER -