Details
| Original language | English |
|---|---|
| Pages (from-to) | 363-367 |
| Number of pages | 5 |
| Journal | Drug Information Journal |
| Volume | 31 |
| Issue number | 2 |
| Publication status | Published - 30 Dec 1997 |
Abstract
Preclinical tests in genetic toxicology represent safety studies. Therefore, the primary concern in the evaluation of Ames test data is the control of the consumer risk, that is, the risk of erroneously concluding safety. Hence, an equivalence test procedure is adequate. This approach is presented beside the two-fold rule and classical tests for differences with respect to an order restricted alternative.
Keywords
- Ames assay, Consumer risk, Difference approach, Equivalence test procedures for ordered many-to-one designs
ASJC Scopus subject areas
- Nursing(all)
- Pharmacology (nursing)
- Medicine(all)
- Drug guides
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Medicine(all)
- Pharmacology (medical)
Sustainable Development Goals
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In: Drug Information Journal, Vol. 31, No. 2, 30.12.1997, p. 363-367.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The control of the consumer risk in the Ames assay
AU - Neuhäuser, Markus
AU - Hothorn, Ludwig A.
PY - 1997/12/30
Y1 - 1997/12/30
N2 - Preclinical tests in genetic toxicology represent safety studies. Therefore, the primary concern in the evaluation of Ames test data is the control of the consumer risk, that is, the risk of erroneously concluding safety. Hence, an equivalence test procedure is adequate. This approach is presented beside the two-fold rule and classical tests for differences with respect to an order restricted alternative.
AB - Preclinical tests in genetic toxicology represent safety studies. Therefore, the primary concern in the evaluation of Ames test data is the control of the consumer risk, that is, the risk of erroneously concluding safety. Hence, an equivalence test procedure is adequate. This approach is presented beside the two-fold rule and classical tests for differences with respect to an order restricted alternative.
KW - Ames assay
KW - Consumer risk
KW - Difference approach
KW - Equivalence test procedures for ordered many-to-one designs
UR - http://www.scopus.com/inward/record.url?scp=0342437485&partnerID=8YFLogxK
U2 - 10.1177/009286159703100207
DO - 10.1177/009286159703100207
M3 - Article
AN - SCOPUS:0342437485
VL - 31
SP - 363
EP - 367
JO - Drug Information Journal
JF - Drug Information Journal
SN - 0092-8615
IS - 2
ER -