Details
| Original language | English |
|---|---|
| Pages (from-to) | 337-341 |
| Number of pages | 5 |
| Journal | Bioprocess Engineering |
| Volume | 23 |
| Issue number | 4 |
| Publication status | Published - Oct 2000 |
Abstract
In this contribution results are presented from the control of glucose during a yeast fed-batch cultivation. For glucose measurements a special flow injection analysis (FIA) system was employed, which uses a glucose oxidase solution instead of immobilized enzymes. To avoid the large delay time caused by probing systems samples containing cells, i.e., samples containing the ordinary culture broth, are injected into the FIA system. Based on a special evaluation method the glucose concentration can be measured with a delay time of about 60 s. Employing an extended Kalman filter, the biomass, the glucose concentration as well as the μmax (Monod model) are estimated. Based on the estimation a feed forward and a PI-control with a set point of 0.5 g/1 was carried out. The mean deviation of the set point and the estimated value as well as the set point and the measured value were 0.05 and 0.11 g/1 respectively for a control period of 8 h producing a cell dry mass of more than 6 g/1.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
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In: Bioprocess Engineering, Vol. 23, No. 4, 10.2000, p. 337-341.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The control of glucose concentration during yeast fed-batch cultivation using a fast measurement complemented by an extended Kalman filter
AU - Hitzmann, B.
AU - Broxtermann, O.
AU - Cha, Y. L.
AU - Sobieh, O.
AU - Stärk, E.
AU - Scheper, T.
PY - 2000/10
Y1 - 2000/10
N2 - In this contribution results are presented from the control of glucose during a yeast fed-batch cultivation. For glucose measurements a special flow injection analysis (FIA) system was employed, which uses a glucose oxidase solution instead of immobilized enzymes. To avoid the large delay time caused by probing systems samples containing cells, i.e., samples containing the ordinary culture broth, are injected into the FIA system. Based on a special evaluation method the glucose concentration can be measured with a delay time of about 60 s. Employing an extended Kalman filter, the biomass, the glucose concentration as well as the μmax (Monod model) are estimated. Based on the estimation a feed forward and a PI-control with a set point of 0.5 g/1 was carried out. The mean deviation of the set point and the estimated value as well as the set point and the measured value were 0.05 and 0.11 g/1 respectively for a control period of 8 h producing a cell dry mass of more than 6 g/1.
AB - In this contribution results are presented from the control of glucose during a yeast fed-batch cultivation. For glucose measurements a special flow injection analysis (FIA) system was employed, which uses a glucose oxidase solution instead of immobilized enzymes. To avoid the large delay time caused by probing systems samples containing cells, i.e., samples containing the ordinary culture broth, are injected into the FIA system. Based on a special evaluation method the glucose concentration can be measured with a delay time of about 60 s. Employing an extended Kalman filter, the biomass, the glucose concentration as well as the μmax (Monod model) are estimated. Based on the estimation a feed forward and a PI-control with a set point of 0.5 g/1 was carried out. The mean deviation of the set point and the estimated value as well as the set point and the measured value were 0.05 and 0.11 g/1 respectively for a control period of 8 h producing a cell dry mass of more than 6 g/1.
UR - http://www.scopus.com/inward/record.url?scp=0034429736&partnerID=8YFLogxK
U2 - 10.1007/s004499900190
DO - 10.1007/s004499900190
M3 - Article
AN - SCOPUS:0034429736
VL - 23
SP - 337
EP - 341
JO - Bioprocess Engineering
JF - Bioprocess Engineering
SN - 0178-515X
IS - 4
ER -