Details
| Original language | English |
|---|---|
| Pages (from-to) | 981-1003 |
| Number of pages | 23 |
| Journal | Synthesis |
| Issue number | 8 |
| Publication status | Published - 2002 |
Abstract
Natural products play a dominant role in providing ligands that interfere with biopolymers such as receptors or enzymes. In many cases the exact mode of action or the targets are not known and synthesis of analogs provides a more detailed insight into the mode of action and helps to identify the protein target. We discuss the synthetic endeavors that led to the synthesis of members of the leptomycin family and will provide a picture of the mode of action.
Keywords
- Anti-tumor, Callystatin A, Leptomycin B, Natural products, Ratjadone
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Organic Chemistry
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In: Synthesis, No. 8, 2002, p. 981-1003.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - The chemistry and biology of the leptomycin family
AU - Kalesse, Markus
AU - Christmann, Mathias
PY - 2002
Y1 - 2002
N2 - Natural products play a dominant role in providing ligands that interfere with biopolymers such as receptors or enzymes. In many cases the exact mode of action or the targets are not known and synthesis of analogs provides a more detailed insight into the mode of action and helps to identify the protein target. We discuss the synthetic endeavors that led to the synthesis of members of the leptomycin family and will provide a picture of the mode of action.
AB - Natural products play a dominant role in providing ligands that interfere with biopolymers such as receptors or enzymes. In many cases the exact mode of action or the targets are not known and synthesis of analogs provides a more detailed insight into the mode of action and helps to identify the protein target. We discuss the synthetic endeavors that led to the synthesis of members of the leptomycin family and will provide a picture of the mode of action.
KW - Anti-tumor
KW - Callystatin A
KW - Leptomycin B
KW - Natural products
KW - Ratjadone
UR - http://www.scopus.com/inward/record.url?scp=0036284115&partnerID=8YFLogxK
U2 - 10.1055/s-2002-31946
DO - 10.1055/s-2002-31946
M3 - Review article
AN - SCOPUS:0036284115
SP - 981
EP - 1003
JO - Synthesis
JF - Synthesis
SN - 0039-7881
IS - 8
ER -