Details
| Original language | English |
|---|---|
| Pages (from-to) | 424-437 |
| Number of pages | 14 |
| Journal | Microbial Cell |
| Volume | 5 |
| Issue number | 10 |
| Early online date | 28 Aug 2018 |
| Publication status | Published - Oct 2018 |
Abstract
Pyoverdines are fluorescent siderophores of pseudomonads that play important roles for growth under iron-limiting conditions. The production of pyoverdines by fluorescent pseudomonads permits their colonization of hosts ranging from humans to plants. Prominent examples include pathogenic or non-pathogenic species such as Pseudomonas aeruginosa, P. putida, P. syringae, or P. fluorescens. Many distinct pyoverdines have been identified, all of which have a dihydroxyquinoline fluorophore in common, derived from oxidative cyclizations of non-ribosomal peptides. These serve as precursor of pyoverdines and are commonly known as ferribactins. Ferribactins of distinct species or even strains often differ in their sequence, resulting in a large variety of pyoverdines. However, synthesis of all ferribactins begins with an L-Glu/D-Tyr/L-Dab sequence, and the fluorophore is generated from the D-Tyr/L-Dab residues. In addition, the initial L-Glu residue is modified to various acids and amides that are responsible for the range of distinguishable pyoverdines in individual strains. While ferribactin synthesis is a cytoplasmic process, the maturation to the fluorescent pyoverdine as well as the tailoring of the initial glutamate are exclusively periplasmic processes that have been a mystery until recently. Here we review the current knowledge of pyoverdine biosynthesis with a focus on the recent advancements regarding the periplasmic maturation and tailoring reactions.
Keywords
- Iron starvation, Non-ribosomal peptide synthetases, Periplasmic tailoring, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pyoverdines, Siderophores
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Immunology and Microbiology (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
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In: Microbial Cell, Vol. 5, No. 10, 10.2018, p. 424-437.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The biosynthesis of pyoverdines
AU - Ringel, Michael T.
AU - Brüser, Thomas
N1 - Funding Information: The publication of this article was funded by the Open Access fund of Leibniz Universität Hannover. This work was supported by grant BR 2285/7-1 of the German Science Foundation (DFG) to TB.
PY - 2018/10
Y1 - 2018/10
N2 - Pyoverdines are fluorescent siderophores of pseudomonads that play important roles for growth under iron-limiting conditions. The production of pyoverdines by fluorescent pseudomonads permits their colonization of hosts ranging from humans to plants. Prominent examples include pathogenic or non-pathogenic species such as Pseudomonas aeruginosa, P. putida, P. syringae, or P. fluorescens. Many distinct pyoverdines have been identified, all of which have a dihydroxyquinoline fluorophore in common, derived from oxidative cyclizations of non-ribosomal peptides. These serve as precursor of pyoverdines and are commonly known as ferribactins. Ferribactins of distinct species or even strains often differ in their sequence, resulting in a large variety of pyoverdines. However, synthesis of all ferribactins begins with an L-Glu/D-Tyr/L-Dab sequence, and the fluorophore is generated from the D-Tyr/L-Dab residues. In addition, the initial L-Glu residue is modified to various acids and amides that are responsible for the range of distinguishable pyoverdines in individual strains. While ferribactin synthesis is a cytoplasmic process, the maturation to the fluorescent pyoverdine as well as the tailoring of the initial glutamate are exclusively periplasmic processes that have been a mystery until recently. Here we review the current knowledge of pyoverdine biosynthesis with a focus on the recent advancements regarding the periplasmic maturation and tailoring reactions.
AB - Pyoverdines are fluorescent siderophores of pseudomonads that play important roles for growth under iron-limiting conditions. The production of pyoverdines by fluorescent pseudomonads permits their colonization of hosts ranging from humans to plants. Prominent examples include pathogenic or non-pathogenic species such as Pseudomonas aeruginosa, P. putida, P. syringae, or P. fluorescens. Many distinct pyoverdines have been identified, all of which have a dihydroxyquinoline fluorophore in common, derived from oxidative cyclizations of non-ribosomal peptides. These serve as precursor of pyoverdines and are commonly known as ferribactins. Ferribactins of distinct species or even strains often differ in their sequence, resulting in a large variety of pyoverdines. However, synthesis of all ferribactins begins with an L-Glu/D-Tyr/L-Dab sequence, and the fluorophore is generated from the D-Tyr/L-Dab residues. In addition, the initial L-Glu residue is modified to various acids and amides that are responsible for the range of distinguishable pyoverdines in individual strains. While ferribactin synthesis is a cytoplasmic process, the maturation to the fluorescent pyoverdine as well as the tailoring of the initial glutamate are exclusively periplasmic processes that have been a mystery until recently. Here we review the current knowledge of pyoverdine biosynthesis with a focus on the recent advancements regarding the periplasmic maturation and tailoring reactions.
KW - Iron starvation
KW - Non-ribosomal peptide synthetases
KW - Periplasmic tailoring
KW - Pseudomonas aeruginosa
KW - Pseudomonas fluorescens
KW - Pyoverdines
KW - Siderophores
UR - http://www.scopus.com/inward/record.url?scp=85065874043&partnerID=8YFLogxK
U2 - 10.15698/mic2018.10.649
DO - 10.15698/mic2018.10.649
M3 - Article
AN - SCOPUS:85065874043
VL - 5
SP - 424
EP - 437
JO - Microbial Cell
JF - Microbial Cell
IS - 10
ER -