Details
| Original language | English |
|---|---|
| Title of host publication | Exploitation of Fungi |
| Subtitle of host publication | Symposium of the British Mycological Society Held at the University of Manchester September 2005 |
| Publisher | Cambridge University Press |
| Pages | 25-44 |
| Number of pages | 20 |
| ISBN (electronic) | 9780511902451 |
| ISBN (print) | 9780521859356 |
| Publication status | Published - 1 Jan 2008 |
| Externally published | Yes |
Abstract
The filamentous fungi are proficient and copious producers of secondary metabolites. From the perspective of an organic chemist, the range and variety of chemical structures of these compounds is remarkable. Synthetic organic chemists have often used the very high structural complexity of fungal secondary metabolites to test their own abilities to mimic nature. From the perspective of a medicinal chemist, the diversity of compounds and structural types represents a pool of useful compounds often possessing unique biological properties. The range of structural types can, at first, appear baffling. However, most secondary metabolites produced by fungi fall into a relatively small number of classes: the alkaloids, derived from amines and amino acids; the terpenoids, derived from isopentenyl diphosphate; and the polyketides, generally derived from acetate. This system of classification is based on the biosynthetic origin of the compound in question, that is to say, a combination of the type of starting material and the type of chemical reactions used during biosynthesis. However, fungi also often combine different types of biosynthetic pathway during the manufacture of secondary metabolites. In Bristol, we have focused our efforts on understanding the biosynthesis of polyketides in fungi, but the inclusion of amino-acid derived moieties in the compounds we are interested in has also necessitated wider investigations.
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- General Immunology and Microbiology
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Exploitation of Fungi: Symposium of the British Mycological Society Held at the University of Manchester September 2005. Cambridge University Press, 2008. p. 25-44.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - The biosynthesis of polyketides, acyl tetramic acids and pyridones by filamentous fungi
AU - Cox, R. J.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - The filamentous fungi are proficient and copious producers of secondary metabolites. From the perspective of an organic chemist, the range and variety of chemical structures of these compounds is remarkable. Synthetic organic chemists have often used the very high structural complexity of fungal secondary metabolites to test their own abilities to mimic nature. From the perspective of a medicinal chemist, the diversity of compounds and structural types represents a pool of useful compounds often possessing unique biological properties. The range of structural types can, at first, appear baffling. However, most secondary metabolites produced by fungi fall into a relatively small number of classes: the alkaloids, derived from amines and amino acids; the terpenoids, derived from isopentenyl diphosphate; and the polyketides, generally derived from acetate. This system of classification is based on the biosynthetic origin of the compound in question, that is to say, a combination of the type of starting material and the type of chemical reactions used during biosynthesis. However, fungi also often combine different types of biosynthetic pathway during the manufacture of secondary metabolites. In Bristol, we have focused our efforts on understanding the biosynthesis of polyketides in fungi, but the inclusion of amino-acid derived moieties in the compounds we are interested in has also necessitated wider investigations.
AB - The filamentous fungi are proficient and copious producers of secondary metabolites. From the perspective of an organic chemist, the range and variety of chemical structures of these compounds is remarkable. Synthetic organic chemists have often used the very high structural complexity of fungal secondary metabolites to test their own abilities to mimic nature. From the perspective of a medicinal chemist, the diversity of compounds and structural types represents a pool of useful compounds often possessing unique biological properties. The range of structural types can, at first, appear baffling. However, most secondary metabolites produced by fungi fall into a relatively small number of classes: the alkaloids, derived from amines and amino acids; the terpenoids, derived from isopentenyl diphosphate; and the polyketides, generally derived from acetate. This system of classification is based on the biosynthetic origin of the compound in question, that is to say, a combination of the type of starting material and the type of chemical reactions used during biosynthesis. However, fungi also often combine different types of biosynthetic pathway during the manufacture of secondary metabolites. In Bristol, we have focused our efforts on understanding the biosynthesis of polyketides in fungi, but the inclusion of amino-acid derived moieties in the compounds we are interested in has also necessitated wider investigations.
UR - http://www.scopus.com/inward/record.url?scp=85011349832&partnerID=8YFLogxK
U2 - 10.1017/CBO9780511902451.004
DO - 10.1017/CBO9780511902451.004
M3 - Contribution to book/anthology
AN - SCOPUS:85011349832
SN - 9780521859356
SP - 25
EP - 44
BT - Exploitation of Fungi
PB - Cambridge University Press
ER -