Details
| Original language | English |
|---|---|
| Article number | 102933 |
| Journal | Advances in Colloid and Interface Science |
| Volume | 318 |
| Early online date | 2 Jun 2023 |
| Publication status | Published - Aug 2023 |
Abstract
Curcumin (Cur), the major bioactive component of turmeric (Curcuma longa) possesses many health benefits. However, low solubility, stability and bioavailability restricts its applications in food. Recently, nanocarriers such as complex coacervates, nanocapsules, liposomes, nanoparticles, nanomicelles, have been used as novel strategies to solve these problems. In this review, we have focused on the delivery systems responsive to the environmental stimuli such as pH-responsive, enzyme-responsive, targeted-to-specific cells or tissues, mucus-penetrating and mucoadhesive carriers. Besides, the metabolites and their biodistribution of Cur and Cur delivery systems are discussed. Most importantly, the interaction between Cur and their carriers with gut microbiota and their effects of modulating the gut health synergistically were discussed comprehensively. In the end, the biocompatibility of Cur delivery systems and the feasibility of their application in food industry is discussed. This review provided a comprehensive review of Cur nanodelivery systems, the health impacts of Cur nanocarriers and an insight into the application of Cur nanocarriers in food industry.
Keywords
- Bioavailability, Curcumin, Encapsulation, Gastrointestinal digestion, Nanocarriers
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Surfaces and Interfaces
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemical Engineering(all)
- Colloid and Surface Chemistry
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In: Advances in Colloid and Interface Science, Vol. 318, 102933, 08.2023.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - The bioavailability, metabolism and microbial modulation of curcumin-loaded nanodelivery systems
AU - Chang, Ruxin
AU - Chen, Liran
AU - Qamar, Muhammad
AU - Wen, Yanjun
AU - Li, Linzheng
AU - Zhang, Jiayin
AU - Li, Xing
AU - Assadpour, Elham
AU - Esatbeyoglu, Tuba
AU - Kharazmi, Mohammad Saeed
AU - Li, Yuan
AU - Jafari, Seid Mahdi
N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (NSFC 31772014 , 31972202 ) and Henan Zhongda Hengyuan Biotechnology Company . The Chinese Ministry of Science and Technology “the Belt and Road” Innovative Talent Exchange Foreign Expert Project (Grant Number DL2021003001 and DL2021014003L ) is also acknowledged.
PY - 2023/8
Y1 - 2023/8
N2 - Curcumin (Cur), the major bioactive component of turmeric (Curcuma longa) possesses many health benefits. However, low solubility, stability and bioavailability restricts its applications in food. Recently, nanocarriers such as complex coacervates, nanocapsules, liposomes, nanoparticles, nanomicelles, have been used as novel strategies to solve these problems. In this review, we have focused on the delivery systems responsive to the environmental stimuli such as pH-responsive, enzyme-responsive, targeted-to-specific cells or tissues, mucus-penetrating and mucoadhesive carriers. Besides, the metabolites and their biodistribution of Cur and Cur delivery systems are discussed. Most importantly, the interaction between Cur and their carriers with gut microbiota and their effects of modulating the gut health synergistically were discussed comprehensively. In the end, the biocompatibility of Cur delivery systems and the feasibility of their application in food industry is discussed. This review provided a comprehensive review of Cur nanodelivery systems, the health impacts of Cur nanocarriers and an insight into the application of Cur nanocarriers in food industry.
AB - Curcumin (Cur), the major bioactive component of turmeric (Curcuma longa) possesses many health benefits. However, low solubility, stability and bioavailability restricts its applications in food. Recently, nanocarriers such as complex coacervates, nanocapsules, liposomes, nanoparticles, nanomicelles, have been used as novel strategies to solve these problems. In this review, we have focused on the delivery systems responsive to the environmental stimuli such as pH-responsive, enzyme-responsive, targeted-to-specific cells or tissues, mucus-penetrating and mucoadhesive carriers. Besides, the metabolites and their biodistribution of Cur and Cur delivery systems are discussed. Most importantly, the interaction between Cur and their carriers with gut microbiota and their effects of modulating the gut health synergistically were discussed comprehensively. In the end, the biocompatibility of Cur delivery systems and the feasibility of their application in food industry is discussed. This review provided a comprehensive review of Cur nanodelivery systems, the health impacts of Cur nanocarriers and an insight into the application of Cur nanocarriers in food industry.
KW - Bioavailability
KW - Curcumin
KW - Encapsulation
KW - Gastrointestinal digestion
KW - Nanocarriers
UR - http://www.scopus.com/inward/record.url?scp=85161345237&partnerID=8YFLogxK
U2 - 10.1016/j.cis.2023.102933
DO - 10.1016/j.cis.2023.102933
M3 - Review article
C2 - 37301064
VL - 318
JO - Advances in Colloid and Interface Science
JF - Advances in Colloid and Interface Science
SN - 0001-8686
M1 - 102933
ER -