Details
| Original language | English |
|---|---|
| Pages (from-to) | 595-598 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 48 |
| Issue number | 3 |
| Publication status | Published - 5 Jan 2009 |
| Externally published | Yes |
Abstract
Three's company: Rhizopodin is a cytostatic macrolide and a potent actin depolymerizer produced by the myxobacterium Myxococcus stipitatus. A crystal structure analysis of the rhizopodin/actin complex reveals that rhizopodin is a C2-symmetric bislactone (see formula). The ternary complex supports the mode of rhizopodin-induced actin dimerization and reveals the absolute configuration and biologically active conformation of this macrolide. (Chemical Equation Presented)
Keywords
- Actin, Inhibitors, Macrolides, Myxobacteria, Rhizopodin
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: Angewandte Chemie - International Edition, Vol. 48, No. 3, 05.01.2009, p. 595-598.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The absolute configuration of rhizopodin and its inhibition of actin polymerization by dimerization
AU - Hagelueken, Gregor
AU - Albrecht, Simone C.
AU - Steinmetz, Heinrich
AU - Jansen, Rolf
AU - Heinz, Dirk W.
AU - Kalesse, Markus
AU - Schubert, Wolf Dieter
PY - 2009/1/5
Y1 - 2009/1/5
N2 - Three's company: Rhizopodin is a cytostatic macrolide and a potent actin depolymerizer produced by the myxobacterium Myxococcus stipitatus. A crystal structure analysis of the rhizopodin/actin complex reveals that rhizopodin is a C2-symmetric bislactone (see formula). The ternary complex supports the mode of rhizopodin-induced actin dimerization and reveals the absolute configuration and biologically active conformation of this macrolide. (Chemical Equation Presented)
AB - Three's company: Rhizopodin is a cytostatic macrolide and a potent actin depolymerizer produced by the myxobacterium Myxococcus stipitatus. A crystal structure analysis of the rhizopodin/actin complex reveals that rhizopodin is a C2-symmetric bislactone (see formula). The ternary complex supports the mode of rhizopodin-induced actin dimerization and reveals the absolute configuration and biologically active conformation of this macrolide. (Chemical Equation Presented)
KW - Actin
KW - Inhibitors
KW - Macrolides
KW - Myxobacteria
KW - Rhizopodin
UR - http://www.scopus.com/inward/record.url?scp=58249117805&partnerID=8YFLogxK
U2 - 10.1002/anie.200802915
DO - 10.1002/anie.200802915
M3 - Article
C2 - 19035596
AN - SCOPUS:58249117805
VL - 48
SP - 595
EP - 598
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 3
ER -