Details
| Original language | English |
|---|---|
| Pages (from-to) | 2931-2932 |
| Number of pages | 2 |
| Journal | Bioinformatics |
| Volume | 29 |
| Issue number | 22 |
| Publication status | Published - 15 Nov 2013 |
| Externally published | Yes |
Abstract
Summary: Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targetedmutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALENoff-targets.We showthat TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning completemammalian genomes within a few minutes.
ASJC Scopus subject areas
- Mathematics(all)
- Statistics and Probability
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Computer Science(all)
- Computer Science Applications
- Computer Science(all)
- Computational Theory and Mathematics
- Mathematics(all)
- Computational Mathematics
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In: Bioinformatics, Vol. 29, No. 22, 15.11.2013, p. 2931-2932.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - TALENoffer: genome-wide TALEN off-target prediction
AU - Grau, Jan
AU - Boch, Jens
AU - Posch, Stefan
N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/11/15
Y1 - 2013/11/15
N2 - Summary: Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targetedmutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALENoff-targets.We showthat TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning completemammalian genomes within a few minutes.
AB - Summary: Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targetedmutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALENoff-targets.We showthat TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning completemammalian genomes within a few minutes.
UR - http://www.scopus.com/inward/record.url?scp=84888090695&partnerID=8YFLogxK
U2 - 10.1093/bioinformatics/btt501
DO - 10.1093/bioinformatics/btt501
M3 - Article
C2 - 23995255
AN - SCOPUS:84888090695
VL - 29
SP - 2931
EP - 2932
JO - Bioinformatics
JF - Bioinformatics
SN - 1367-4803
IS - 22
ER -