TALE and TALEN genome editing technologies

Research output: Contribution to journal › Article › Research › peer review

Authors

  • Sebastian Becker
  • Jens Boch

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Original languageGerman
Article number100007
JournalGene and Genome Editing
Volume2
Early online date28 May 2021
Publication statusPublished - Dec 2021

Abstract

TALEN were the first easy-to-use genome editing technology and sparked the genome editing revolution. Their application in multiple species brought targeted mutagenesis to the attention of scientists worldwide. Key breakthrough successes of genome editing have since been achieved using TALEN, among these, the first commercialization of an edited crop and the first human cured from cancer. TALEN have since been largely replaced by the CRISPR technologies which are somewhat easier to build, much easier to multiplex, and have spawned multiple derived techniques. Nevertheless, the flexible and precise positioning of TALEN is unmatched, and thus they have continued to evolve to new functionalities. Here, we assemble essential facts, design guidelines as well as important past and exciting novel developments.

Cite this

TALE and TALEN genome editing technologies. / Becker, Sebastian; Boch, Jens.
In: Gene and Genome Editing, Vol. 2, 100007, 12.2021.

Research output: Contribution to journal › Article › Research › peer review

Becker, S & Boch, J 2021, 'TALE and TALEN genome editing technologies', Gene and Genome Editing, vol. 2, 100007. https://doi.org/10.1016/j.ggedit.2021.100007
Becker, S., & Boch, J. (2021). TALE and TALEN genome editing technologies. Gene and Genome Editing, 2, Article 100007. https://doi.org/10.1016/j.ggedit.2021.100007
Becker S, Boch J. TALE and TALEN genome editing technologies. Gene and Genome Editing. 2021 Dec;2:100007. Epub 2021 May 28. doi: 10.1016/j.ggedit.2021.100007
Becker, Sebastian ; Boch, Jens. / TALE and TALEN genome editing technologies. In: Gene and Genome Editing. 2021 ; Vol. 2.
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