Details
| Original language | English |
|---|---|
| Pages (from-to) | 693-701 |
| Number of pages | 9 |
| Journal | Natural product reports |
| Volume | 38 |
| Issue number | 4 |
| Publication status | Published - 19 Oct 2020 |
| Externally published | Yes |
Abstract
Covering: 1975-2020 The ibophyllidine alkaloids are unique pyrroloindole alkaloids exhibiting a five-membered D-ring in contrast to the six-membered D-ring of the more common Aspidosperma and Strychnos alkaloids. This structural feature has made them sought-after targets for organic chemists as well as for the elucidation of their biosynthesis. Beginning with the first and eponymous member ibophyllidine, isolation and structure determination is discussed. The main focus of this review are the diverse chemical approaches towards the ibophyllidines in context with their respective biosynthesis. The often employed Diels-Alder reaction strategy, two other named reaction-based strategies and the most recent enantioselective strategies are presented and compared.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural product reports, Vol. 38, No. 4, 19.10.2020, p. 693-701.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Synthetic strategies for the ibophyllidine alkaloids
AU - Reuss, Franziska
AU - Heretsch, Philipp
N1 - Funding Information: FR is grateful for a PhD scholarship from the Studienstiung des Deutschen Volkes.
PY - 2020/10/19
Y1 - 2020/10/19
N2 - Covering: 1975-2020 The ibophyllidine alkaloids are unique pyrroloindole alkaloids exhibiting a five-membered D-ring in contrast to the six-membered D-ring of the more common Aspidosperma and Strychnos alkaloids. This structural feature has made them sought-after targets for organic chemists as well as for the elucidation of their biosynthesis. Beginning with the first and eponymous member ibophyllidine, isolation and structure determination is discussed. The main focus of this review are the diverse chemical approaches towards the ibophyllidines in context with their respective biosynthesis. The often employed Diels-Alder reaction strategy, two other named reaction-based strategies and the most recent enantioselective strategies are presented and compared.
AB - Covering: 1975-2020 The ibophyllidine alkaloids are unique pyrroloindole alkaloids exhibiting a five-membered D-ring in contrast to the six-membered D-ring of the more common Aspidosperma and Strychnos alkaloids. This structural feature has made them sought-after targets for organic chemists as well as for the elucidation of their biosynthesis. Beginning with the first and eponymous member ibophyllidine, isolation and structure determination is discussed. The main focus of this review are the diverse chemical approaches towards the ibophyllidines in context with their respective biosynthesis. The often employed Diels-Alder reaction strategy, two other named reaction-based strategies and the most recent enantioselective strategies are presented and compared.
UR - http://www.scopus.com/inward/record.url?scp=85102847043&partnerID=8YFLogxK
U2 - 10.1039/d0np00036a
DO - 10.1039/d0np00036a
M3 - Article
VL - 38
SP - 693
EP - 701
JO - Natural product reports
JF - Natural product reports
SN - 0265-0568
IS - 4
ER -