Details
| Original language | English |
|---|---|
| Article number | SS-2012-Z0646-OP |
| Pages (from-to) | 3822-3828 |
| Number of pages | 7 |
| Journal | Synthesis |
| Volume | 44 |
| Issue number | 24 |
| Publication status | Published - 2012 |
Abstract
Directed ortho-lithiation of estrone carbamate followed by reaction with electrophiles afforded 2-substituted estrone derivatives. Reductive cleavage of the carbamate group followed by O-allylation and Claisen rearrangement led to new 4-functionalized estrone derivatives.
Keywords
- carbanions, Claisen rearrangement, estrone, ortho -lithiation, steroids
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Organic Chemistry
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In: Synthesis, Vol. 44, No. 24, SS-2012-Z0646-OP, 2012, p. 3822-3828.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Synthetic approaches towards 4-functionalized estrone derivatives
AU - Schön, Uwe
AU - Messinger, Josef
AU - Solodenko, Wladimir
AU - Kirschning, Andreas
PY - 2012
Y1 - 2012
N2 - Directed ortho-lithiation of estrone carbamate followed by reaction with electrophiles afforded 2-substituted estrone derivatives. Reductive cleavage of the carbamate group followed by O-allylation and Claisen rearrangement led to new 4-functionalized estrone derivatives.
AB - Directed ortho-lithiation of estrone carbamate followed by reaction with electrophiles afforded 2-substituted estrone derivatives. Reductive cleavage of the carbamate group followed by O-allylation and Claisen rearrangement led to new 4-functionalized estrone derivatives.
KW - carbanions
KW - Claisen rearrangement
KW - estrone
KW - ortho -lithiation
KW - steroids
UR - http://www.scopus.com/inward/record.url?scp=84870880272&partnerID=8YFLogxK
U2 - 10.1055/s-0032-1316816
DO - 10.1055/s-0032-1316816
M3 - Article
AN - SCOPUS:84870880272
VL - 44
SP - 3822
EP - 3828
JO - Synthesis
JF - Synthesis
SN - 0039-7881
IS - 24
M1 - SS-2012-Z0646-OP
ER -