Details
| Original language | English |
|---|---|
| Pages (from-to) | 3553-3556 |
| Number of pages | 4 |
| Journal | Tetrahedron letters |
| Volume | 40 |
| Issue number | 18 |
| Publication status | Published - 30 Apr 1999 |
Abstract
The synthesis of the strained epothilone analog containing a ten- membered ring as well as the northern hemisphere of epothilone A is described. This approach, using the ring closing metathesis reaction, is a solution to the lack of stereocontrol observed in the ring closing metathesis reaction utilized in the synthesis of the epothilone backbone by other groups.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Tetrahedron letters, Vol. 40, No. 18, 30.04.1999, p. 3553-3556.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Synthesis of the northern hemisphere of epothilone A by a ten-membered ring closing metathesis reaction
AU - Gerlach, Kai
AU - Quitschalle, Monika
AU - Kalesse, Markus
PY - 1999/4/30
Y1 - 1999/4/30
N2 - The synthesis of the strained epothilone analog containing a ten- membered ring as well as the northern hemisphere of epothilone A is described. This approach, using the ring closing metathesis reaction, is a solution to the lack of stereocontrol observed in the ring closing metathesis reaction utilized in the synthesis of the epothilone backbone by other groups.
AB - The synthesis of the strained epothilone analog containing a ten- membered ring as well as the northern hemisphere of epothilone A is described. This approach, using the ring closing metathesis reaction, is a solution to the lack of stereocontrol observed in the ring closing metathesis reaction utilized in the synthesis of the epothilone backbone by other groups.
UR - http://www.scopus.com/inward/record.url?scp=0033617388&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(99)00550-X
DO - 10.1016/S0040-4039(99)00550-X
M3 - Article
AN - SCOPUS:0033617388
VL - 40
SP - 3553
EP - 3556
JO - Tetrahedron letters
JF - Tetrahedron letters
SN - 0040-4039
IS - 18
ER -