Details
| Original language | English |
|---|---|
| Pages (from-to) | 1108-1110 |
| Number of pages | 3 |
| Journal | SYNLETT |
| Issue number | 10 |
| Publication status | Published - Oct 1998 |
Abstract
The synthesis of the C7-C17 segment of epothilones employing a ring closing metathesis is described. Our approach utilizes the stereoselective methylation of the 10-membered lactone, generated by ring closing metathesis, for introducing the methyl group at C8 and provides an efficient access to strained epothilone derivatives, as well as to the C7-C17 segment of epothilones.
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
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In: SYNLETT, No. 10, 10.1998, p. 1108-1110.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Synthesis of the C7-C17 segment of epothilones by a 10-membered ring closing metathesis reaction
AU - Gerlach, Kai
AU - Quitschalle, Monika
AU - Kalesse, Markus
PY - 1998/10
Y1 - 1998/10
N2 - The synthesis of the C7-C17 segment of epothilones employing a ring closing metathesis is described. Our approach utilizes the stereoselective methylation of the 10-membered lactone, generated by ring closing metathesis, for introducing the methyl group at C8 and provides an efficient access to strained epothilone derivatives, as well as to the C7-C17 segment of epothilones.
AB - The synthesis of the C7-C17 segment of epothilones employing a ring closing metathesis is described. Our approach utilizes the stereoselective methylation of the 10-membered lactone, generated by ring closing metathesis, for introducing the methyl group at C8 and provides an efficient access to strained epothilone derivatives, as well as to the C7-C17 segment of epothilones.
UR - http://www.scopus.com/inward/record.url?scp=0001897541&partnerID=8YFLogxK
U2 - 10.1055/s-1998-1870
DO - 10.1055/s-1998-1870
M3 - Article
AN - SCOPUS:0001897541
SP - 1108
EP - 1110
JO - SYNLETT
JF - SYNLETT
SN - 0936-5214
IS - 10
ER -