Synthesis of a C20-Deoxygenated Spirangien Derivative for Target Identification

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Original languageEnglish
Pages (from-to)797-801
Number of pages5
JournalSYNLETT
Volume26
Issue number6
Publication statusPublished - 2015

Abstract

The synthesis of a C20-deoxygenated spirangien derivative is described that allows the incorporation of various affinity labels for target identification of this potent natural product. The synthesis takes advantage of two major building blocks that can be accessed in 8 and 14 steps, respectively. The endgame joins both fragments through a selective aldol reaction and final protecting group manipulations furnish the target molecule.

Keywords

    aldol reaction, natural product synthesis, spirangien, target identification

ASJC Scopus subject areas

Cite this

Synthesis of a C20-Deoxygenated Spirangien Derivative for Target Identification. / Bluhm, Nadine; Kalesse, Markus.
In: SYNLETT, Vol. 26, No. 6, 2015, p. 797-801.

Research output: Contribution to journal › Article › Research › peer review

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AU - Kalesse, Markus

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