Details
| Original language | English |
|---|---|
| Pages (from-to) | 797-801 |
| Number of pages | 5 |
| Journal | SYNLETT |
| Volume | 26 |
| Issue number | 6 |
| Publication status | Published - 2015 |
Abstract
The synthesis of a C20-deoxygenated spirangien derivative is described that allows the incorporation of various affinity labels for target identification of this potent natural product. The synthesis takes advantage of two major building blocks that can be accessed in 8 and 14 steps, respectively. The endgame joins both fragments through a selective aldol reaction and final protecting group manipulations furnish the target molecule.
Keywords
- aldol reaction, natural product synthesis, spirangien, target identification
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
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In: SYNLETT, Vol. 26, No. 6, 2015, p. 797-801.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Synthesis of a C20-Deoxygenated Spirangien Derivative for Target Identification
AU - Bluhm, Nadine
AU - Kalesse, Markus
N1 - Publisher Copyright: © Georg Thieme Verlag.
PY - 2015
Y1 - 2015
N2 - The synthesis of a C20-deoxygenated spirangien derivative is described that allows the incorporation of various affinity labels for target identification of this potent natural product. The synthesis takes advantage of two major building blocks that can be accessed in 8 and 14 steps, respectively. The endgame joins both fragments through a selective aldol reaction and final protecting group manipulations furnish the target molecule.
AB - The synthesis of a C20-deoxygenated spirangien derivative is described that allows the incorporation of various affinity labels for target identification of this potent natural product. The synthesis takes advantage of two major building blocks that can be accessed in 8 and 14 steps, respectively. The endgame joins both fragments through a selective aldol reaction and final protecting group manipulations furnish the target molecule.
KW - aldol reaction
KW - natural product synthesis
KW - spirangien
KW - target identification
UR - http://www.scopus.com/inward/record.url?scp=84925493612&partnerID=8YFLogxK
U2 - 10.1055/s-0034-1379980
DO - 10.1055/s-0034-1379980
M3 - Article
AN - SCOPUS:84925493612
VL - 26
SP - 797
EP - 801
JO - SYNLETT
JF - SYNLETT
SN - 0936-5214
IS - 6
ER -