Details
| Original language | English |
|---|---|
| Pages (from-to) | 245-256 |
| Number of pages | 12 |
| Journal | Carbohydrate Research |
| Volume | 256 |
| Issue number | 2 |
| Publication status | Published - 1 Apr 1994 |
| Externally published | Yes |
Abstract
The synthesis of 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate (15), the first committed intermediate in a new branch of the shikimate pathway of aromatic biosynthesis, is reported from 2-deoxy-d-glucose in 14 steps in 10-12% overall yield.
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Organic Chemistry
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In: Carbohydrate Research, Vol. 256, No. 2, 01.04.1994, p. 245-256.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Synthesis of 4-amino 3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate, the biosynthetic precursor of C7N units in ansamycin antibiotics
AU - Kirschning, Andreas
AU - Bergon, Philippe
AU - Wang, Jeh Jeng
AU - Breazeale, Steven
AU - Floss, Heinz G.
N1 - Funding information: This work was supportedb y the National Institutes of Health through research grant AI 20264a nd by the Alexander von Humboldt Foundation, Bad Godesberg, through a Lynen Postdoctoral Fellowship to A.K.
PY - 1994/4/1
Y1 - 1994/4/1
N2 - The synthesis of 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate (15), the first committed intermediate in a new branch of the shikimate pathway of aromatic biosynthesis, is reported from 2-deoxy-d-glucose in 14 steps in 10-12% overall yield.
AB - The synthesis of 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate (15), the first committed intermediate in a new branch of the shikimate pathway of aromatic biosynthesis, is reported from 2-deoxy-d-glucose in 14 steps in 10-12% overall yield.
UR - http://www.scopus.com/inward/record.url?scp=0028413961&partnerID=8YFLogxK
U2 - 10.1016/0008-6215(94)84211-6
DO - 10.1016/0008-6215(94)84211-6
M3 - Article
C2 - 8187101
AN - SCOPUS:0028413961
VL - 256
SP - 245
EP - 256
JO - Carbohydrate Research
JF - Carbohydrate Research
SN - 0008-6215
IS - 2
ER -